Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes

• Published in: BMC genomics Vol. 18; no. 1; p. 39
• Main Authors: Lateef, Zabeen, Gimenez, Gregory, Baker, Estelle S., Ward, Vernon K.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.01.2017; BioMed Central
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Amino Acid Sequence; Animals; Binding sites; Caliciviridae Infections - virology; Caspase; Cell Line; Cells, Cultured; Chemokines; Cloning; Cytokines; Enzymes; Gene Expression Profiling; Gene Expression Regulation, Viral; Genetic aspects; Genetic transcription; Genomes; Genomics; Humans; Immune system; Infections; Intracellular signalling; Localization; MAP kinase; Mass spectrometry; Mice; Monocytes; Monocytes - virology; Next-generation sequencing; NF-κB protein; Norovirus; Norovirus - physiology; Pandemics; Phosphorylation; Phylogeny; Protein Conformation, alpha-Helical; Proteins; Ribonucleic acid; RNA; RNA sequencing; Scientific imaging; Signal Transduction; Signaling; Stem cells; Toll-like receptors; Toll-Like Receptors - metabolism; Transcriptome; Transcriptomics; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - genetics; Viral Nonstructural Proteins - metabolism; Viruses; NS1-2; Human norovirus (HuNoV); Murine norovirus (MNV); Transcriptomic analysis; RNAseq; Disordered protein

The GII.4 Sydney 2012 strain of human norovirus (HuNoV) is a pandemic strain that is responsible for the majority of norovirus outbreaks in healthcare settings. The function of the non-structural (NS)1-2 protein from HuNoV is unknown. In silico analysis of human norovirus NS1-2 protein showed that i...