Profiling of the antibody response to attenuated LC16m8 smallpox vaccine using protein array analysis

• Published in: Vaccine Vol. 37; no. 44; pp. 6588 - 6593
• Main Authors: Eto, Akiko, Fujita, Masanori, Nishiyama, Yasumasa, Saito, Tomoya, Molina, Douglas M., Morikawa, Shigeru, Saijo, Masayuki, Shinmura, Yasuhiko, Kanatani, Yasuhiro
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 16.10.2019; Elsevier Limited
• Subjects: adults; Allergy and Immunology; Antibodies; antibody formation; Antibody profiling; Antibody response; Antigens; Arrays; Bioterrorism; blood serum; Cell culture; Data analysis; E coli; Effectiveness; Experiments; Funding; Human; immunodominant epitopes; Immunogenicity; Immunoglobulins; Infectious diseases; LC16m8; Medical equipment; Neutralization; Protein array; Protein arrays; protein microarrays; Proteins; Proteomes; Self defense; Smallpox; Smallpox vaccine; Statistical analysis; Strains (organisms); vaccination; Vaccines; Vaccinia virus; virion; Virions; Viruses; United States > US; Japan; LC16m8; Human; Protein array; IMV; Smallpox vaccine; EEV; WR; PRN; Antibody profiling; WHO; World Health Organization; plaque-reduction neutralizing; Western Reserve strain; intracellular mature virion; extracellular enveloped virion

Concerns about bioterrorism and outbreaks of zoonotic orthopoxvirus require safe and efficacious smallpox vaccines. We previously reported the clinical efficacy and safety profiles of LC16m8, a live, attenuated, cell culture-derived, smallpox vaccine, examined in over 3000 healthy Japanese adults wi...