Role of germinal centers for the induction of broadly-reactive memory B cells

• Published in: Current opinion in immunology Vol. 45; pp. 119 - 125
• Main Authors: Takahashi, Yoshimasa, Kelsoe, Garnett
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2017
• Subjects: Allergy and Immunology; Animals; Antigens, Viral - immunology; B-Lymphocytes - immunology; Cell Proliferation; Cell Survival - immunology; Epitopes - immunology; Germinal Center - immunology; Germinal Center - virology; Humans; Immunologic Memory; Viruses - immunology

•Viral conserved domains are often concealed from the humoral responses.•Memory B cells counteract with viral mutations by germline-encoded cross-reactivity.•GC reactions fine-tune the specificity of memory B cells toward the conserved domains.•Permissive GC selection allows the fine-tuning of memor...