Circadian Rhythms, Sleep, and Disorders of Aging

Sleep–wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian regulation contributes to the loss of neural function. As cir...

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Published inTrends in endocrinology and metabolism Vol. 27; no. 4; pp. 192 - 203
Main Authors Mattis, Joanna, Sehgal, Amita
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.04.2016
Subjects
aging
Aging - physiology
Alzheimer Disease
Alzheimer's
Animals
Chronobiology Disorders
Circadian Rhythm - physiology
circadian rhythms
Endocrinology & Metabolism
Humans
Huntington's
neurodegeneration
Neurodegenerative Diseases
Parkinson Disease
Parkinson's
sleep
Sleep - physiology
Sleep Wake Disorders
sleep
Parkinson's
neurodegeneration
aging
circadian rhythms
Alzheimer's
Huntington's
Online AccessGet full text
ISSN1043-2760
1879-3061
1879-3061
DOI10.1016/j.tem.2016.02.003

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Abstract Sleep–wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian regulation contributes to the loss of neural function. As circadian rhythms and sleep consolidation also break down with normal aging, changes in these may be part of what makes aging a risk factor for disorders like Alzheimer's disease (AD). Mechanisms underlying the connection between circadian/sleep dysregulation and neurodegeneration remain unclear, but several recent studies provide interesting possibilities. While mechanistic analysis is under way, it is worth considering treatment of circadian/sleep disruption as a means to alleviate symptoms of neurodegenerative disorders. Sleep and circadian dysfunction are increasingly being associated with neurodegenerative disorders. Earlier studies with human subjects are now supported by findings in genetic models. Circadian and sleep circuits are damaged in disorders like Huntington's and Parkinson's disease and disrupted sleep/circadian rhythms may exacerbate disease pathology. Thus, these two processes may feed back on each other. Metabolic factors may provide a mechanistic link between circadian rhythms, sleep, and neurodegenerative disorders. Sleep and circadian dysregulation could provide a screening tool to identify populations at risk for neurodegenerative disorders.
AbstractList Sleep–wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian regulation contributes to the loss of neural function. As circadian rhythms and sleep consolidation also break down with normal aging, changes in these may be part of what makes aging a risk factor for disorders like Alzheimer's disease (AD). Mechanisms underlying the connection between circadian/sleep dysregulation and neurodegeneration remain unclear, but several recent studies provide interesting possibilities. While mechanistic analysis is under way, it is worth considering treatment of circadian/sleep disruption as a means to alleviate symptoms of neurodegenerative disorders. Sleep and circadian dysfunction are increasingly being associated with neurodegenerative disorders. Earlier studies with human subjects are now supported by findings in genetic models. Circadian and sleep circuits are damaged in disorders like Huntington's and Parkinson's disease and disrupted sleep/circadian rhythms may exacerbate disease pathology. Thus, these two processes may feed back on each other. Metabolic factors may provide a mechanistic link between circadian rhythms, sleep, and neurodegenerative disorders. Sleep and circadian dysregulation could provide a screening tool to identify populations at risk for neurodegenerative disorders.
Sleep-wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian regulation contributes to the loss of neural function. As circadian rhythms and sleep consolidation also break down with normal aging, changes in these may be part of what makes aging a risk factor for disorders like Alzheimer's disease (AD). Mechanisms underlying the connection between circadian/sleep dysregulation and neurodegeneration remain unclear, but several recent studies provide interesting possibilities. While mechanistic analysis is under way, it is worth considering treatment of circadian/sleep disruption as a means to alleviate symptoms of neurodegenerative disorders.
Sleep:wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian regulation contributes to the loss of neural function. As circadian rhythms and sleep consolidation also break down with normal aging, changes in these may be part of what makes aging a risk factor for disorders like Alzheimer's disease. Mechanisms underlying the connection between circadian/sleep dysregulation and neurodegeneration remain unclear, but several recent studies provide interesting possibilities. While mechanistic analysis is underway, it is worth considering treatment of circadian/sleep disruption as a means to alleviate symptoms of neurodegenerative disorders.
Sleep-wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian regulation contributes to the loss of neural function. As circadian rhythms and sleep consolidation also break down with normal aging, changes in these may be part of what makes aging a risk factor for disorders like Alzheimer's disease (AD). Mechanisms underlying the connection between circadian/sleep dysregulation and neurodegeneration remain unclear, but several recent studies provide interesting possibilities. While mechanistic analysis is under way, it is worth considering treatment of circadian/sleep disruption as a means to alleviate symptoms of neurodegenerative disorders.Sleep-wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian regulation contributes to the loss of neural function. As circadian rhythms and sleep consolidation also break down with normal aging, changes in these may be part of what makes aging a risk factor for disorders like Alzheimer's disease (AD). Mechanisms underlying the connection between circadian/sleep dysregulation and neurodegeneration remain unclear, but several recent studies provide interesting possibilities. While mechanistic analysis is under way, it is worth considering treatment of circadian/sleep disruption as a means to alleviate symptoms of neurodegenerative disorders.
Author Mattis, Joanna
Sehgal, Amita
AuthorAffiliation 1
2 amita@mail.med.upenn.edu
AuthorAffiliation_xml – name: 1
– name: 2 amita@mail.med.upenn.edu
Author_xml – sequence: 1
  givenname: Joanna
  surname: Mattis
  fullname: Mattis, Joanna
  organization: Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
– sequence: 2
  givenname: Amita
  surname: Sehgal
  fullname: Sehgal, Amita
  email: amita@mail.med.upenn.edu
  organization: HHMI, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26947521$$D View this record in MEDLINE/PubMed
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Cho (bib1415) 2001; 4
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Snippet Sleep–wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of...
Sleep-wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of...
Sleep:wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of...
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SubjectTerms aging
Aging - physiology
Alzheimer Disease
Alzheimer's
Animals
Chronobiology Disorders
Circadian Rhythm - physiology
circadian rhythms
Endocrinology & Metabolism
Humans
Huntington's
neurodegeneration
Neurodegenerative Diseases
Parkinson Disease
Parkinson's
sleep
Sleep - physiology
Sleep Wake Disorders
Title Circadian Rhythms, Sleep, and Disorders of Aging
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https://dx.doi.org/10.1016/j.tem.2016.02.003
https://www.ncbi.nlm.nih.gov/pubmed/26947521
https://www.proquest.com/docview/1776086213
https://pubmed.ncbi.nlm.nih.gov/PMC4808513
Volume 27
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