Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

• Published in: Nature immunology Vol. 20; no. 3; pp. 362 - 372
• Main Authors: Kanekiyo, Masaru, Joyce, M. Gordon, Gillespie, Rebecca A., Gallagher, John R., Andrews, Sarah F., Yassine, Hadi M., Wheatley, Adam K., Fisher, Brian E., Ambrozak, David R., Creanga, Adrian, Leung, Kwanyee, Yang, Eun Sung, Boyoglu-Barnum, Seyhan, Georgiev, Ivelin S., Tsybovsky, Yaroslav, Prabhakaran, Madhu S., Andersen, Hanne, Kong, Wing-Pui, Baxa, Ulrich, Zephir, Kathryn L., Ledgerwood, Julie E., Koup, Richard A., Kwong, Peter D., Harris, Audray K., McDermott, Adrian B., Mascola, John R., Graham, Barney S.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2019; Nature Publishing Group
• Subjects: 631/250/2152/2153/1291; 631/326/596/1578; 631/61/24/590/2294; Animals; Antibodies; Antibodies, Neutralizing - administration & dosage; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Antigens; Avidity; B cells; B-Lymphocytes - drug effects; B-Lymphocytes - immunology; B-Lymphocytes - virology; Biomedical and Life Sciences; Biomedicine; Composition; Cross Reactions - drug effects; Cross Reactions - immunology; Discordance; Displays (Marketing); Female; Glycoproteins; Health aspects; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinins; Humans; Immune response; Immunization; Immunodominance; Immunologic research; Immunology; Infectious Diseases; Influenza; Influenza A; Influenza A Virus, H1N1 Subtype - immunology; Influenza A Virus, H1N1 Subtype - metabolism; Influenza A Virus, H1N1 Subtype - physiology; Influenza vaccines; Influenza Vaccines - administration & dosage; Influenza Vaccines - chemistry; Influenza Vaccines - immunology; Influenza viruses; Influenza, Human - immunology; Influenza, Human - prevention & control; Influenza, Human - virology; Lectins; Lymphocytes B; Mice, Inbred BALB C; Monoclonal antibodies; Nanoparticles; Nanoparticles - chemistry; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - prevention & control; Orthomyxoviridae Infections - virology; Strains (organisms); Swine influenza; Vaccine efficacy; Vaccines; Viruses

The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against influenza. Here we designed a vaccine using the hy...