Critical Roles for Lipomannan and Lipoarabinomannan in Cell Wall Integrity of Mycobacteria and Pathogenesis of Tuberculosis

• Published in: mBio Vol. 4; no. 1; p. e00472
• Main Authors: Fukuda, Takeshi, Matsumura, Takayuki, Ato, Manabu, Hamasaki, Maho, Nishiuchi, Yukiko, Murakami, Yoshiko, Maeda, Yusuke, Yoshimori, Tamotsu, Matsumoto, Sohkichi, Kobayashi, Kazuo, Kinoshita, Taroh, Morita, Yasu S.
• Format: Journal Article
• Language: English
• Published: United States American Society of Microbiology 01.03.2013; American Society for Microbiology
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; beta-lactam antibiotics; beta-lactams; beta-Lactams - pharmacology; biochemical pathways; Cell Wall - metabolism; Cell Wall - physiology; cell wall components; cell walls; drug therapy; Female; glycolipids; immunomodulation; Lipopolysaccharides - metabolism; macrophages; Macrophages - immunology; Macrophages - microbiology; mannose; Mice; Mice, Inbred C57BL; Microbial Viability; mutants; Mycobacterium smegmatis; Mycobacterium smegmatis - drug effects; Mycobacterium smegmatis - metabolism; Mycobacterium smegmatis - pathogenicity; Mycobacterium smegmatis - physiology; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - metabolism; Mycobacterium tuberculosis - pathogenicity; Mycobacterium tuberculosis - physiology; pathogenesis; people; polymers; protective effect; tuberculosis; Tuberculosis - microbiology; virulence

Lipomannan (LM) and lipoarabinomannan (LAM) are mycobacterial glycolipids containing a long mannose polymer. While they are implicated in immune modulations, the significance of LM and LAM as structural components of the mycobacterial cell wall remains unknown. We have previously reported that a bra...