ADAMTS9 Is a Cell-Autonomously Acting, Anti-Angiogenic Metalloprotease Expressed by Microvascular Endothelial Cells

• Published in: The American journal of pathology Vol. 176; no. 3; pp. 1494 - 1504
• Main Authors: Koo, Bon-Hun, Coe, David M., Dixon, Laura J., Somerville, Robert P.T., Nelson, Courtney M., Wang, Lauren W., Young, Mary Elizabeth, Lindner, Daniel J., Apte, Suneel S.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.03.2010; ASIP; American Society for Investigative Pathology
• Subjects: ADAM Proteins - genetics; ADAM Proteins - metabolism; ADAMTS9 Protein; Aging - metabolism; Animals; Biocatalysis; Biological and medical sciences; Cell Movement; Corneal Neovascularization - enzymology; Corneal Neovascularization - pathology; Embryo, Mammalian - enzymology; Embryo, Mammalian - pathology; Endothelial Cells - enzymology; Endothelial Cells - pathology; Enzyme Activation; Gene Knockdown Techniques; Humans; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Mice; Mice, Inbred C57BL; Microvessels - enzymology; Microvessels - pathology; Neoplasm Transplantation; Neoplasms - blood supply; Neoplasms - enzymology; Neoplasms - pathology; Neovascularization, Pathologic - enzymology; Neovascularization, Pathologic - pathology; Organ Specificity; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Phosphorylation; Receptors, Vascular Endothelial Growth Factor - metabolism; Regular; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA, Small Interfering - metabolism; Thrombospondin 1 - metabolism; Thrombospondins - metabolism; Vascular Endothelial Growth Factor A - metabolism; Microcirculation; Anatomic pathology; Endothelial cell; Antiangiogenic agent

The metalloprotease ADAMTS9 participates in melanoblast development and is a tumor suppressor in esophageal and nasopharyngeal cancer. ADAMTS9 null mice die before gastrulation, but, ADAMTS9 +/− mice were initially thought to be normal. However, when congenic with the C57Bl/6 strain, 80% of ADAMTS9...