TREM2 is associated with the risk of Alzheimer's disease in Spanish population

• Published in: Neurobiology of aging Vol. 34; no. 6; pp. 1711.e15 - 1711.e17
• Main Authors: Benitez, Bruno A., Cooper, Breanna, Pastor, Pau, Jin, Sheng-Chih, Lorenzo, Elena, Cervantes, Sebastian, Cruchaga, Carlos
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2013
• Subjects: Adult; Age; Aged; Aged, 80 and over; Alzheimer; Alzheimer Disease - diagnosis; Alzheimer Disease - ethnology; Alzheimer Disease - genetics; Association; European Continental Ancestry Group - ethnology; European Continental Ancestry Group - genetics; Female; Genetic Association Studies - methods; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Humans; Internal Medicine; Male; Membrane Glycoproteins - genetics; Middle Aged; Neurology; Receptors, Immunologic - genetics; Replication; rs75932628; Spain - ethnology; Spanish; TREM2; Spain; Replication; TREM2; Spanish; Association; rs75932628; Alzheimer

Two recent studies have reported the association of rs75932628-T in the TREM2 gene with the risk for Alzheimer's disease (AD). Rs75932628-T is a rare nonsynonymous variant (p.R47H) that confers a high risk of AD with an effect size similar to that of the APOE ɛ4 allele. However, this associatio...