High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults

• Published in: Neurobiology of aging Vol. 65; pp. 158 - 167
• Main Authors: Hiscox, Lucy V., Johnson, Curtis L., McGarry, Matthew D.J., Perrins, Michael, Littlejohn, Aimee, van Beek, Edwin J.R., Roberts, Neil, Starr, John M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2018; Elsevier
• Subjects: Adolescent; Adult; Aged; Brain; Cerebrum - anatomy & histology; Cerebrum - diagnostic imaging; Cerebrum - pathology; Elasticity; Elasticity imaging techniques; Elasticity Imaging Techniques - methods; Elastography; Female; Gray Matter - anatomy & histology; Gray Matter - diagnostic imaging; Gray Matter - pathology; Healthy aging; Healthy Aging - pathology; Healthy Aging - physiology; Humans; Image Enhancement - methods; Magnetic resonance elastography (MRE); Male; Organ Size; Subcortical gray matter; Viscoelasticity; Viscosity; Young Adult; Viscoelasticity; Brain; Magnetic resonance elastography (MRE); Subcortical gray matter; Elasticity imaging techniques; Healthy aging; Elastography

Volumetric structural magnetic resonance imaging (MRI) is commonly used to determine the extent of neuronal loss in aging, indicated by cerebral atrophy. The brain, however, exhibits other biophysical characteristics such as mechanical properties, which can be quantified with magnetic resonance elas...