Analysis of serum lysophosphatidylethanolamine levels in patients with non-alcoholic fatty liver disease by liquid chromatography-tandem mass spectrometry

• Published in: Analytical and bioanalytical chemistry Vol. 413; no. 1; pp. 245 - 254
• Main Authors: Yamamoto, Yusuke, Sakurai, Toshihiro, Chen, Zhen, Furukawa, Takayuki, Gowda, Siddabasave Gowda B., Wu, Yue, Nouso, Kazuhiro, Fujii, Yuki, Yoshikawa, Yuki, Chiba, Hitoshi, Hui, Shu-Ping
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2021; Springer; Springer Nature B.V
• Subjects: Analysis; Analytical Chemistry; Biochemistry; blood serum; Cephalin; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Chromatography; Diagnostic systems; Fatty liver; Food Science; hydrolysis; Identification and classification; Laboratory Medicine; Liquid chromatography; Liver; Liver diseases; Mass spectrometry; Mass spectroscopy; Methods; Monitoring/Environmental Analysis; Phosphatidylethanolamine; phosphatidylethanolamines; Quantitation; quantitative analysis; Research Paper; Scientific imaging; Serum; Species; Spectroscopy; Steatosis; tandem mass spectrometry; Japan; LysoPE; Lysophosphatidylethanolamine; Liquid chromatography-tandem mass spectrometry; Chemical synthesis; Non-alcoholic fatty liver disease

Lysophosphatidylethanolamines (LysoPEs) are the partial hydrolysis products of phosphatidylethanolamine. Despite the unique in vitro bioactivities of LysoPEs, there are limited reports on the pathophysiological role of LysoPEs in the serum, due to the lack of sensitive analytical methods for determi...