Evaluation of plasma anti-GPL-core IgA and IgG for diagnosis of disseminated non-tuberculous mycobacteria infection

• Published in: PloS one Vol. 15; no. 11; p. e0242598
• Main Authors: Nithichanon, Arnone, Samer, Waraporn, Chetchotisakd, Ploenchan, Kewcharoenwong, Chidchamai, Ato, Manabu, Lertmemongkolchai, Ganjana
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.11.2020; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Antibodies; Antibodies, Bacterial - blood; Antibodies, Bacterial - immunology; Antigens; Autoantibodies; Bacterial infections; Biology and Life Sciences; Blood & organ donations; Diagnosis; Diagnostic systems; Enzyme-linked immunosorbent assay; Ethics; Female; Glycopeptides - immunology; Health aspects; Hospitals; Humans; Immunoglobulin A; Immunoglobulin A - blood; Immunoglobulin A - immunology; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunology; Infections; Infectious diseases; Laboratories; Lung diseases; Lymphadenopathy; Male; Medical diagnosis; Medicine; Medicine and Health Sciences; Melioidosis; Middle Aged; Mycobacteria; Mycobacterium avium Complex - immunology; Mycobacterium avium Complex - isolation & purification; Mycobacterium avium-intracellulare Infection - blood; Mycobacterium avium-intracellulare Infection - diagnosis; Mycobacterium avium-intracellulare Infection - epidemiology; Mycobacterium avium-intracellulare Infection - immunology; Physiological aspects; Plasma; R&D; Research & development; Research and Analysis Methods; Thailand - epidemiology; Tuberculosis; Young Adult; γ-Interferon; Thailand; United States > US; Switzerland; Japan

Detection of IgA antibody against Mycobacterium avium complex (MAC) glycopeptidolipid (GPL) has recently been shown to improve the diagnosis of MAC pulmonary disease but has yet to be tested in disseminated Non-tuberculous mycobacteria (NTM) infection. In this study, we address the diagnostic effica...