Laser-engineered dissolving microneedle arrays for protein delivery: potential for enhanced intradermal vaccination

• Published in: Journal of pharmacy and pharmacology Vol. 67; no. 3; p. 409
• Main Authors: McCrudden, Maelíosa T C, Torrisi, Barbara M, Al-Zahrani, Sharifah, McCrudden, Cian M, Zaric, Marija, Scott, Christopher J, Kissenpfennig, Adrien, McCarthy, Helen O, Donnelly, Ryan F
• Format: Journal Article
• Language: English
• Published: England 01.03.2015
• Subjects: Administration, Cutaneous; Animals; Antigens - administration & dosage; Drug Delivery Systems; Interferon-gamma - blood; Interleukin-4 - blood; Lasers; Maleates - chemistry; Methyl Ethers - chemistry; Mice; Microinjections; Needles; Ovalbumin - administration & dosage; Polyvinyls - chemistry; Skin - metabolism; Skin Absorption; Solubility; Vaccination - methods; Vaccines - administration & dosage; microneedles; laser-engineering; protein delivery; vaccination

We aimed to highlight the utility of novel dissolving microneedle (MN)-based delivery systems for enhanced transdermal protein delivery. Vaccination remains the most accepted and effective approach in offering protection from infectious diseases. In recent years, much interest has focused on the pos...