Gene-specific DNA methylation may mediate atypical antipsychotic-induced insulin resistance

• Published in: Bipolar disorders Vol. 18; no. 5; pp. 423 - 432
• Main Authors: Burghardt, Kyle J, Goodrich, Jacyln M, Dolinoy, Dana C, Ellingrod, Vicki L
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.08.2016
• Subjects: Adult; Aldehyde Oxidoreductases - genetics; Antipsychotic Agents - administration & dosage; Antipsychotic Agents - adverse effects; antipsychotics; bipolar disorder; Bipolar Disorder - drug therapy; DNA Methylation - drug effects; Epigenesis, Genetic; Female; Genome-Wide Association Study; Humans; insulin; Insulin Resistance - physiology; Male; mediation; methylation; Pharmacogenetics; Prospective Studies; Reproducibility of Results; antipsychotics; bipolar disorder; mediation; insulin; methylation

Objectives Atypical antipsychotics (AAPs) carry a significant risk of cardiometabolic side effects, including insulin resistance. It is thought that the insulin resistance resulting from the use of AAPs may be associated with changes in DNA methylation. We aimed to identify and validate a candidate...