role for T cell-derived interleukin 22 in psoriatic skin inflammation

• Published in: Clinical and experimental immunology Vol. 150; no. 3; pp. 407 - 415
• Main Authors: Boniface, K, Guignouard, E, Pedretti, N, Garcia, M, Delwail, A, Bernard, F.-X, Nau, F, Guillet, G, Dagregorio, G, Yssel, H, Lecron, J.-C, Morel, F
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.12.2007; Blackwell Publishing Ltd; Blackwell; Wiley; Blackwell Science Inc
• Subjects: Adaptive immunology; Adult; Aged; Aged, 80 and over; Analytical, structural and metabolic biochemistry; Biochemistry; Biochemistry, Molecular Biology; Biological and medical sciences; biosynthesis; Cells, Cultured; cytokines; Dermatology; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling; Gene Expression Profiling - methods; genetics; Human health and pathology; Humans; Immunology; inflammation; Inflammation Mediators; Inflammation Mediators - metabolism; Innate immunity; Interleukin-22; Interleukins; Interleukins - biosynthesis; Interleukins - genetics; Interleukins - immunology; Keratinocytes; Keratinocytes - immunology; Life Sciences; Male; metabolism; methods; Middle Aged; Molecular and cellular biology; Molecular biophysics; psoriasis; Psoriasis - immunology; Receptors, Interleukin; Receptors, Interleukin - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction - methods; RNA, Messenger; RNA, Messenger - genetics; Skin; Skin - immunology; skin disease; T cells; T-lymphocytes; T-Lymphocytes - immunology; Translational Studies; Up-Regulation; Skin disease; Psoriasis; Cytokine; T-Lymphocyte; Interleukin 22; Biochemistry; Inflammation; Skin; cytokines; Biophysics; Molecular biology; T cells

Interleukin (IL)-22 is a T cell-derived cytokine that has been reported recently to induce cutaneous inflammation in an experimental murine model of psoriasis, and to induce in vitro an inflammatory-like phenotype. In the present study, we assessed the presence of IL-22 and the IL-22 receptor 1 (IL-...