Direct Inhibition by Nitric Oxide of the Transcriptional Ferric Uptake Regulation Protein via Nitrosylation of the Iron

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 99; no. 26; pp. 16619 - 16624
• Main Authors: D'Autréaux, Benoît, Touati, Danièle, Bersch, Beate, Latour, Jean-Marc, Michaud-Soret, Isabelle
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 24.12.2002; National Acad Sciences
• Subjects: Aerobic conditions; Bacteria; Bacterial Proteins; Bacterial Proteins - antagonists & inhibitors; Bacterial Proteins - chemistry; Bacterial Proteins - physiology; Biochemistry; Biochemistry, Molecular Biology; Biological Sciences; Chelating agents; Deoxyribonucleic acid; Diethylamines; Dimerization; Dimers; DNA; E coli; Electron Spin Resonance Spectroscopy; Escherichia coli; Gene expression regulation; Iron; Iron - metabolism; Life Sciences; Ligands; Nitric Oxide; Nitric Oxide - physiology; Oxidative stress; Plasmids; Promoter regions; Protein Conformation; Proteins; Repressor Proteins; Repressor Proteins - antagonists & inhibitors; Repressor Proteins - chemistry; Repressor Proteins - physiology; Transcription, Genetic; metalloregulator; iron; nitric oxide; escherichia coli; transcription

Ferric uptake regulation protein (Fur) is a bacterial global regulator that uses iron as a cofactor to bind to specific DNA sequences. The function of Fur is not limited to iron homeostasis. A wide variety of genes involved in various mechanisms such as oxidative and acid stresses are under Fur cont...