Ability of Rabeprazole to Prevent Gastric Mucosal Damage From Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype

• Published in: Clinical gastroenterology and hepatology Vol. 10; no. 8; pp. 879 - 885.e2
• Main Authors: Uotani, Takahiro, Sugimoto, Mitsushige, Nishino, Masafumi, Kodaira, Chise, Yamade, Mihoko, Sahara, Shu, Yamada, Takanori, Osawa, Satoshi, Sugimoto, Ken, Tanaka, Tatsuo, Umemura, Kazuo, Watanabe, Hiroshi, Miyajima, Hiroaki, Furuta, Takahisa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2012
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage; Adult; Anti-Ulcer Agents - administration & dosage; Aryl Hydrocarbon Hydroxylases - genetics; Asian Continental Ancestry Group; Aspirin - administration & dosage; Aspirin - adverse effects; Cardiovascular; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Interactions; Endoscopy, Gastrointestinal; Female; Gastric Mucosa - pathology; Gastroenterology and Hepatology; Genotype; Humans; Male; Peptic Ulcer - prevention & control; PPI; Rabeprazole; Severity of Illness Index; Stomach; Ticlopidine - administration & dosage; Ticlopidine - adverse effects; Ticlopidine - analogs & derivatives; Treatment Outcome; Young Adult; Stomach; AC; ARU; IM; Cardiovascular; NSAID; PPI; LDA; CYP2C19; GSRS; Drug Interactions; MLS; PG; VN; IPA; RM; PM; modified Lanza score; proton pump inhibitor; inhibition of platelet aggregation; pepsinogen; aspirin reaction unit; S-mephenytoin 4′-hydroxylase; Verify Now system; poor metabolizer; Gastrointestinal Symptom Rating Scale; intermediate metabolizer; rapid metabolizer; low-dose aspirin; aspirin and clopidogrel; nonsteroidal anti-inflammatory drug

Low doses of aspirin can injure the gastric mucosa. It is not clear whether other drugs such as the antiplatelet agent clopidogrel also cause gastric mucosal injury or exacerbate aspirin-induced injury, or whether proton pump inhibitors prevent damage. Twenty Japanese subjects with different CYP2C19...