Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice

• Published in: Nature genetics Vol. 39; no. 8; pp. 1025 - 1032
• Main Authors: Andrews, Nancy C, Wang, Fudi, Paradkar, Prasad N, Custodio, Angel O, McVey Ward, Diane, Fleming, Mark D, Campagna, Dean, Roberts, Kristina A, Boyartchuk, Victor, Dietrich, William F, Kaplan, Jerry
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2007; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Animals; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cation Transport Proteins - genetics; Cation Transport Proteins - metabolism; Cellular biology; Chromosomes; Chromosomes, Mammalian; Crosses, Genetic; Diagnosis; Female; Gene Function; Gene mapping; Genetic aspects; Genetic diversity; Genetic variation; Genetics; Human Genetics; Iron; Iron - metabolism; Iron metabolism disorders; letter; Liver - metabolism; Macrophages - metabolism; Male; Mammals; Mice; Mice, Inbred Strains; Physiological aspects; Protein Transport; Quantitative Trait Loci; Risk factors; RNA, Small Interfering; Rodents; Trafficking; United States

We undertook a quantitative trait locus (QTL) analysis in mice to identify modifier genes that might influence the severity of human iron disorders. We identified a strong QTL on mouse chromosome 9 that differentially affected macrophage iron burden in C57BL/10J and SWR/J mice. A C57BL/10J missense...