Steroids-producing nodules: a two-layered adrenocortical nodular structure as a precursor lesion of cortisol-producing adenoma

• Published in: EBioMedicine Vol. 103; p. 105087
• Main Authors: Fukumoto, Tazuru, Umakoshi, Hironobu, Iwahashi, Norifusa, Ogasawara, Tatsuki, Yokomoto-Umakoshi, Maki, Kaneko, Hiroki, Fujita, Masamichi, Uchida, Naohiro, Nakao, Hiroshi, Kawamura, Namiko, Matsuda, Yayoi, Sakamoto, Ryuichi, Miyazawa, Takashi, Seki, Masahide, Eto, Masatoshi, Oda, Yoshinao, Suzuki, Yutaka, Ogawa, Seishi, Ogawa, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2024
• Subjects: Adenoma - genetics; Adenoma - metabolism; Adenoma - pathology; Adrenal androgen; Adrenal Cortex - metabolism; Adrenal Cortex - pathology; Adrenal Cortex Neoplasms - genetics; Adrenal Cortex Neoplasms - metabolism; Adrenal Cortex Neoplasms - pathology; Adrenocortical Adenoma - genetics; Adrenocortical Adenoma - metabolism; Adrenocortical Adenoma - pathology; Adrenocortical tumorigenesis; Advanced Basic Science; Clonal expansion; Cortisol-producing adenoma; Cushing's syndrome; Female; Gene Expression Profiling; GNAS; Humans; Hydrocortisone - metabolism; Internal Medicine; Male; Middle Aged; Mutation; Steroids - biosynthesis; Steroids - metabolism; Transcriptome; Adrenal androgen; GNAS; Cortisol-producing adenoma; Adrenocortical tumorigenesis; Cushing's syndrome; Clonal expansion

The human adrenal cortex consists of three functionally and structurally distinct layers; zona glomerulosa, zona fasciculata (zF), and zona reticularis (zR), and produces adrenal steroid hormones in a layer-specific manner; aldosterone, cortisol, and adrenal androgens, respectively. Cortisol-produci...