Serotonin Affects Transcranial Direct Current–Induced Neuroplasticity in Humans

• Published in: Biological psychiatry (1969) Vol. 66; no. 5; pp. 503 - 508
• Main Authors: Nitsche, Michael A., Kuo, Min-Fang, Karrasch, Ralf, Wächter, Bettina, Liebetanz, David, Paulus, Walter
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2009
• Subjects: Adult; Citalopram - pharmacology; Cross-Over Studies; Depression; Electric Stimulation - methods; Evoked Potentials, Motor - drug effects; Evoked Potentials, Motor - physiology; Female; human; Humans; Male; motor cortex; Motor Cortex - drug effects; Motor Cortex - physiology; Neuronal Plasticity - drug effects; Neuronal Plasticity - physiology; neuroplasticity; Psychiatry; serotonin; Serotonin - physiology; Serotonin Uptake Inhibitors - pharmacology; transcranial direct current stimulation; Transcranial Magnetic Stimulation; Depression; serotonin; motor cortex; human; transcranial direct current stimulation; neuroplasticity

Modulation of the serotonergic system affects long-term potentiation (LTP) and long-term depression (LTD), the likely neurophysiologic derivates of learning and memory formation, in animals and slice preparations. Serotonin-dependent modulation of plasticity has been proposed as an underlying mechan...