Plasma miR-124 as a biomarker for cerebral infarction

MicroRNAs (miRNAs) are endogenous small RNAs that play an important role in various physiological processes by downregulating target genes. Recently, plasma miRNAs have been investigated as biomarkers for various diseases. In this study, miRNA array analysis in various tissues showed that miR-124 is...

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Published inBiomedical Research Vol. 32; no. 2; pp. 135 - 141
Main Authors Weng, Huachun, Shen, Chunshen, Hirokawa, Gou, Ji, Xu, Takahashi, Rie, Shimada, Kana, Kishimoto, Chiharu, Iwai, Naoharu
Format Journal Article
LanguageEnglish
Published Japan Biomedical Research Press 01.04.2011
Japan Science and Technology Agency
Subjects
Animals
Biomarkers - blood
Brain - metabolism
Brain - pathology
Cells, Cultured
Cerebral Infarction - blood
Cerebral Infarction - diagnosis
Cerebral Infarction - etiology
Cerebral Infarction - pathology
Disease Models, Animal
Early Diagnosis
Gene Expression Profiling
Humans
Infarction, Middle Cerebral Artery - complications
Infarction, Middle Cerebral Artery - pathology
Male
MicroRNAs - blood
Oligonucleotide Array Sequence Analysis
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
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Abstract MicroRNAs (miRNAs) are endogenous small RNAs that play an important role in various physiological processes by downregulating target genes. Recently, plasma miRNAs have been investigated as biomarkers for various diseases. In this study, miRNA array analysis in various tissues showed that miR-124 is almost exclusively expressed in the central nervous system and neuronal cells, suggesting that it might be useful as a potential biomarker for neurological diseases. We examined whether plasma concentrations of brain-specific miRNA can serve as a biomarker for cerebral infarction, where the cerebral infarction was modeled by middle cerebral artery occlusion (MCAO) in the rat. Plasma concentrations of miR-124 were significantly elevated at 6 h, and remained elevated at 48 h after MCAO introduction. Thus, plasma concentration of miR-124 provides a promising candidate biomarker for early detection of cerebral infarction.
AbstractList MicroRNAs (miRNAs) are endogenous small RNAs that play an important role in various physiological processes by downregulating target genes. Recently, plasma miRNAs have been investigated as biomarkers for various diseases. In this study, miRNA array analysis in various tissues showed that miR-124 is almost exclusively expressed in the central nervous system and neuronal cells, suggesting that it might be useful as a potential biomarker for neurological diseases. We examined whether plasma concentrations of brain-specific miRNA can serve as a biomarker for cerebral infarction, where the cerebral infarction was modeled by middle cerebral artery occlusion (MCAO) in the rat. Plasma concentrations of miR-124 were significantly elevated at 6 h, and remained elevated at 48 h after MCAO introduction. Thus, plasma concentration of miR-124 provides a promising candidate biomarker for early detection of cerebral infarction.
Author Hirokawa, Gou
Ji, Xu
Weng, Huachun
Shen, Chunshen
Shimada, Kana
Kishimoto, Chiharu
Iwai, Naoharu
Takahashi, Rie
Author_xml – sequence: 1
  fullname: Weng, Huachun
  organization: Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka 565-8565, Japan
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  fullname: Shen, Chunshen
  organization: Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka 565-8565, Japan
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  fullname: Hirokawa, Gou
  organization: Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka 565-8565, Japan
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  fullname: Ji, Xu
  organization: Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka 565-8565, Japan
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  fullname: Takahashi, Rie
  organization: Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka 565-8565, Japan
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  fullname: Shimada, Kana
  organization: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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  fullname: Kishimoto, Chiharu
  organization: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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  fullname: Iwai, Naoharu
  organization: Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka 565-8565, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21551949$$D View this record in MEDLINE/PubMed
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Snippet MicroRNAs (miRNAs) are endogenous small RNAs that play an important role in various physiological processes by downregulating target genes. Recently, plasma...
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pubmed
jstage
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Index Database
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StartPage 135
SubjectTerms Animals
Biomarkers - blood
Brain - metabolism
Brain - pathology
Cells, Cultured
Cerebral Infarction - blood
Cerebral Infarction - diagnosis
Cerebral Infarction - etiology
Cerebral Infarction - pathology
Disease Models, Animal
Early Diagnosis
Gene Expression Profiling
Humans
Infarction, Middle Cerebral Artery - complications
Infarction, Middle Cerebral Artery - pathology
Male
MicroRNAs - blood
Oligonucleotide Array Sequence Analysis
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Title Plasma miR-124 as a biomarker for cerebral infarction
URI https://www.jstage.jst.go.jp/article/biomedres/32/2/32_2_135/_article/-char/en
https://www.ncbi.nlm.nih.gov/pubmed/21551949
https://www.proquest.com/docview/1467764468
https://search.proquest.com/docview/865695388
Volume 32
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