Production of ent-kaurene from lignocellulosic hydrolysate in Rhodosporidium toruloides

• Published in: Microbial cell factories Vol. 19; no. 1; pp. 24 - 12
• Main Authors: Geiselman, Gina M., Zhuang, Xun, Kirby, James, Tran-Gyamfi, Mary B., Prahl, Jan-Philip, Sundstrom, Eric R., Gao, Yuqian, Munoz Munoz, Nathalie, Nicora, Carrie D., Clay, Derek M., Papa, Gabriella, Burnum-Johnson, Kristin E., Magnuson, Jon K., Tanjore, Deepti, Skerker, Jeffrey M., Gladden, John M.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.02.2020; BioMed Central; BMC
• Subjects: Adenine; Adenosine monophosphate; Basidiomycota; Biological products; Bioreactors; Carbon; Cellulose; Chemical plants; Chemical properties; Corn; Cultivation; Deconstruction; Diterpene; Diterpenes; Elongation; Engineers; Enzymes; Gene expression; Geranylgeranyl pyrophosphate synthase; Gibberella fujikuroi; Lignin; Lignocellulose; Metabolic engineering; Methods; Mevalonate pathway; Monomers; Mutant farnesyl pyrophosphate synthase; Mutants; Mutation; Novels; Nucleotides; Phosphates; Production processes; Proteins; Purines; Raw materials; Rhodosporidium toruloides; Rhodotorula; Sesquiterpenes; Stover; Sugar; Therapeutics; Translation elongation; Translocase; China; Diterpene; Geranylgeranyl pyrophosphate synthase; Metabolic engineering; Mutant farnesyl pyrophosphate synthase; Mevalonate pathway; Rhodotorula

Rhodosporidium toruloides has emerged as a promising host for the production of bioproducts from lignocellulose, in part due to its ability to grow on lignocellulosic feedstocks, tolerate growth inhibitors, and co-utilize sugars and lignin-derived monomers. Ent-kaurene derivatives have a diverse ran...