Clonal Population of Flucytosine-Resistant Candida tropicalis from Blood Cultures, Paris, France

Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this stud...

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Published in	Emerging infectious diseases Vol. 14; no. 4; pp. 557 - 565
Main Authors	Desnos-Ollivier, Marie, Bretagne, Stéphane, Bernède, Claire, Robert, Vincent, Raoux, Dorothée, Chachaty, Elisabeth, Forget, Elisabeth, Lacroix, Claire, Dromer, Françoise
Format	Journal Article
Language	English
Published	United States U.S. National Center for Infectious Diseases 01.04.2008 Centers for Disease Control and Prevention
Subjects	Antifungal Agents - pharmacology antifungal drug resistance Ascomycetes Blood Candida tropicalis Candida tropicalis - classification Candida tropicalis - drug effects Candida tropicalis - genetics candidemia Candidiasis - microbiology Drug Resistance, Fungal Flucytosine Flucytosine - pharmacology France Fungemia - microbiology Genotype Health aspects Humans Medical examination Microsatellite Repeats multilocus sequence typing Phenotype polymorphic microsatellite markers Risk Factors Time Factors France
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Abstract	Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone.
AbstractList	Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone. Such isolates are widespread around clinical centers and are associated with malignancies that cause fewer deaths than other C. tropicalis isolates. Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone. Such isolates are widespread around clinical centers and are associated with malignancies that cause fewer deaths than other C. tropicalis isolates. Candida tropicalis is a diploid ascomycetes yeast responsible for 4%–24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone. Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone.Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone.
Audience	Professional Academic
Author	Desnos-Ollivier, Marie Lacroix, Claire Bernède, Claire Forget, Elisabeth Dromer, Françoise Robert, Vincent Bretagne, Stéphane Chachaty, Elisabeth Raoux, Dorothée
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Snippet	Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. Resistance to flucytosine is rarely described for this species but was... Such isolates are widespread around clinical centers and are associated with malignancies that cause fewer deaths than other C. tropicalis isolates. Candida... Such isolates are widespread around clinical centers and are associated with malignancies that cause fewer deaths than other C. tropicalis isolates. Candida... Candida tropicalis is a diploid ascomycetes yeast responsible for 4%–24% of candidemia. Resistance to flucytosine is rarely described for this species but was...
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SubjectTerms	Antifungal Agents - pharmacology antifungal drug resistance Ascomycetes Blood Candida tropicalis Candida tropicalis - classification Candida tropicalis - drug effects Candida tropicalis - genetics candidemia Candidiasis - microbiology Drug Resistance, Fungal Flucytosine Flucytosine - pharmacology France Fungemia - microbiology Genotype Health aspects Humans Medical examination Microsatellite Repeats multilocus sequence typing Phenotype polymorphic microsatellite markers Risk Factors Time Factors
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Title	Clonal Population of Flucytosine-Resistant Candida tropicalis from Blood Cultures, Paris, France
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