ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors

• Published in: Cancer letters Vol. 328; no. 1; pp. 144 - 151
• Main Authors: Huang, Cheng-Po, Tsai, Meng-Feng, Chang, Tzu-Hua, Tang, Wei-Chien, Chen, Su-Yu, Lai, Hsiao-Hsuan, Lin, Ting-Yu, Yang, James Chih-Hsin, Yang, Pan-Chyr, Shih, Jin-Yuan, Lin, Shwu-Bin
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.01.2013; Elsevier Limited
• Subjects: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase - analysis; Aldehyde dehydrogenase 1A1; analysis; Animals; antagonists & inhibitors; Antineoplastic Agents; Antineoplastic Agents - pharmacology; Cancer stem cell; Cancer therapies; cell culture; Cell Line, Tumor; chemistry; Chemotherapy; drug effects; Drug resistance; Drug Resistance, Neoplasm; drug therapy; drugs; Epidermal growth factor; epidermal growth factor receptors; ErbB Receptors; Flow cytometry; Gefitinib resistance; Gene amplification; Gene expression; Hematology, Oncology and Palliative Medicine; Humans; Kinases; Lung cancer; lung neoplasms; Lung Neoplasms - drug therapy; Male; Medical prognosis; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Neoplastic Stem Cells; Neoplastic Stem Cells - chemistry; Neoplastic Stem Cells - drug effects; pharmacology; Protein Kinase Inhibitors; Protein Kinase Inhibitors - pharmacology; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Rodents; Stem cells; Studies; tyrosine; Tyrosine kinase inhibitor; Cancer stem cell; Aldehyde dehydrogenase 1A1; Tyrosine kinase inhibitor; Lung cancer; Gefitinib resistance

► ALDH1A1-positive lung cancer cells display significant resistance to EGFR-TKI. ► ALDH1A1-positive population is enriched in EGFR TKI resistance lung cancer cells. ► Clinical studies are consistent with results from cell culture model systems. ► We report that cancer stem cells confer resistance to...