ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors - Huang, Cheng-Po; Tsai, Meng-Feng; Chang, Tzu-Hua; Tang, Wei-Chien; Chen, Su-Yu; Lai, Hsiao-Hsuan; Lin, Ting-Yu; Yang, James Chih-Hsin; Yang, Pan-Chyr; Shih, Jin-Yuan; Lin, Shwu-Bin (Cancer letters, 2013)
Keywords: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase - analysis; Aldehyde dehydrogenase 1A1; analysis; Animals; antagonists & inhibitors; Antineoplastic Agents; Antineoplastic Agents - pharmacology; Cancer stem cell; Cancer therapies; cell culture; Cell Line, Tumor; chemistry; Chemotherapy; drug effects; Drug resistance; Drug Resistance, Neoplasm; drug therapy; drugs; Epidermal growth factor; epidermal growth factor receptors; ErbB Receptors; Flow cytometry; Gefitinib resistance; Gene amplification; Gene expression; Hematology, Oncology and Palliative Medicine; Humans; Kinases; Lung cancer; lung neoplasms; Lung Neoplasms - drug therapy; Male; Medical prognosis; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Neoplastic Stem Cells; Neoplastic Stem Cells - chemistry; Neoplastic Stem Cells - drug effects; pharmacology; Protein Kinase Inhibitors; Protein Kinase Inhibitors - pharmacology; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Rodents; Stem cells; Studies; tyrosine; Tyrosine kinase inhibitor; Cancer stem cell; Aldehyde dehydrogenase 1A1; Tyrosine kinase inhibitor; Lung cancer; Gefitinib resistance