Alterations of white matter integrity related to motor activity in schizophrenia

• Published in: Neurobiology of disease Vol. 42; no. 3; pp. 276 - 283
• Main Authors: Walther, Sebastian, Federspiel, Andrea, Horn, Helge, Razavi, Nadja, Wiest, Roland, Dierks, Thomas, Strik, Werner, Müller, Thomas J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2011; Elsevier
• Subjects: Actigraphy; Adult; Anisotropy; Brain - pathology; Brain - physiopathology; Brain Mapping; Diffusion Tensor Imaging; Disconnection; Female; Fractional anisotropy; Humans; Image Processing, Computer-Assisted; Linear Models; Male; Motor Activity - physiology; Nerve Fibers, Myelinated - pathology; Nerve Fibers, Myelinated - physiology; Neurology; Schizophrenia - pathology; Schizophrenia - physiopathology; Supplemental motor area; Actigraphy; Fractional anisotropy; Supplemental motor area; Disconnection

Altered structural connectivity is a key finding in schizophrenia, but the meaning of white matter alterations for behavior is rarely studied. In healthy subjects, motor activity correlated with white matter integrity in motor tracts. To explore the relation of motor activity and fractional anisotro...