Molecular landmarks of tumor hypoxia across cancer types

• Published in: Nature genetics Vol. 51; no. 2; pp. 308 - 318
• Main Authors: Bhandari, Vinayak, Hoey, Christianne, Liu, Lydia Y., Lalonde, Emilie, Ray, Jessica, Livingstone, Julie, Lesurf, Robert, Shiah, Yu-Jia, Vujcic, Tina, Huang, Xiaoyong, Espiritu, Shadrielle M. G., Heisler, Lawrence E., Yousif, Fouad, Huang, Vincent, Yamaguchi, Takafumi N., Yao, Cindy Q., Sabelnykova, Veronica Y., Fraser, Michael, Chua, Melvin L. K., van der Kwast, Theodorus, Liu, Stanley K., Boutros, Paul C., Bristow, Robert G.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2019; Nature Publishing Group
• Subjects: 38; 45; 45/23; 45/61; 45/91; 631/208/212/2166; 631/67/1857; 631/67/327; 631/67/589; Agriculture; Analysis; Animal Genetics and Genomics; Anoxia; Automation; Bioinformatics; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer metastasis; Cancer Research; Chromosomes; Constellations; Deoxyribonucleic acid; Discovery tools; DNA; Gene expression; Gene Function; Gene mutation; Genomes; Genomic instability; Human Genetics; Hypoxia; Metabolism; Metastases; MicroRNA; miRNA; Mutation; Ovarian cancer; Oxygen; Phenotypes; Prostate cancer; PTEN protein; Stability; Telomeres; Thyroid gland; Tumors

Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia. Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular hallmarks of tumor hypoxia remain poorly defined. To fill this gap, we quantified hypoxia in 8,006 tumors across 19 tumor...