De novo gene signature identification from single‐cell RNA‐seq with hierarchical Poisson factorization - Levitin, Hanna Mendes; Yuan, Jinzhou; Cheng, Yim Ling; Ruiz, Francisco JR; Bush, Erin C; Bruce, Jeffrey N; Canoll, Peter; Iavarone, Antonio; Lasorella, Anna; Blei, David M; Sims, Peter A (Molecular systems biology, 2019)
Keywords: Artificial intelligence; Bayes Theorem; Bayesian analysis; Budgets; Cell cycle; Datasets; dimensionality reduction; EMBO09; EMBO17; Factorization; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene sequencing; gene signature discovery; Genomes; Genomics; Glioblastoma; Glioma; Glioma - genetics; Glioma - pathology; Glioma cells; High-Throughput Nucleotide Sequencing - methods; Humans; Method; Methods; Physiology; Poisson Distribution; Principal components analysis; Ribonucleic acid; RNA; Single-Cell Analysis; single‐cell RNA‐seq; Sparsity; Statistics; Subpopulations; Survival; Temporal variations; Transcriptome - genetics; single‐cell RNA‐seq; glioma; dimensionality reduction; gene signature discovery