Exploiting Supramolecular Synthons in Designing Gelators Derived from Multiple Drugs

A simple strategy for designing salt‐based supramolecular gelators comprised of various nonsteroidal anti‐inflammatory drugs (NSAIDs) and amantadine (AMN) (an antiviral drug) has been demonstrated using a supramolecular synthon approach. Single‐crystal and powder X‐ray diffraction established the ex...

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Published in	Chemistry : a European journal Vol. 20; no. 47; pp. 15320 - 15324
Main Authors	Roy, Rajdip, Deb, Jolly, Jana, Siddhartha Sankar, Dastidar, Parthasarathi
Format	Journal Article
Language	English
Published	Weinheim WILEY-VCH Verlag 17.11.2014 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Subjects	Amantadine Amantadine - chemistry Amantadine - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biocompatibility Biocompatible Materials - chemistry Cell Line Chemistry crystal engineering Diclofenac - chemistry Diclofenac - pharmacology Diffraction Dinoprostone - metabolism drug delivery Drug therapy Drugs Gels - chemistry Ingredients Interferon-gamma - pharmacology Lipopolysaccharides - toxicity LMWGS Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice Nonsteroidal anti-inflammatory drugs Rheology Salicylates Salicylates - chemistry Salts - chemistry Strategy supramolecular gels supramolecular synthons X-rays supramolecular synthons LMWGS drug delivery crystal engineering supramolecular gels
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Abstract	A simple strategy for designing salt‐based supramolecular gelators comprised of various nonsteroidal anti‐inflammatory drugs (NSAIDs) and amantadine (AMN) (an antiviral drug) has been demonstrated using a supramolecular synthon approach. Single‐crystal and powder X‐ray diffraction established the existence of the well‐studied gel‐forming 1D supramolecular synthon, namely, primary ammonium monocarboxylate (PAM) synthon in all the salts. Remarkably five out of six salts were found to be capable of gelling methyl salicylate (MS)—an important ingredient in commercially available topical gels; one such selected biocompatible salt displayed an anti‐inflammatory response in prostaglandin E2 (PGE2) assay, thereby indicating their plausible biomedical applications. A supramolecular synthon approach enables an easy access (through salt formation) to a series of supramolecular gelators derived from nonsteroidal anti‐inflammatory drugs (NSAIDs) and amantadine. Biocompatibility and anti‐inflammatory response of the gelator salts indicate their plausible use in biomedical applications (see figure).
AbstractList	A simple strategy for designing salt‐based supramolecular gelators comprised of various nonsteroidal anti‐inflammatory drugs (NSAIDs) and amantadine (AMN) (an antiviral drug) has been demonstrated using a supramolecular synthon approach. Single‐crystal and powder X‐ray diffraction established the existence of the well‐studied gel‐forming 1D supramolecular synthon, namely, primary ammonium monocarboxylate (PAM) synthon in all the salts. Remarkably five out of six salts were found to be capable of gelling methyl salicylate (MS)—an important ingredient in commercially available topical gels; one such selected biocompatible salt displayed an anti‐inflammatory response in prostaglandin E2 (PGE2) assay, thereby indicating their plausible biomedical applications. A supramolecular synthon approach enables an easy access (through salt formation) to a series of supramolecular gelators derived from nonsteroidal anti‐inflammatory drugs (NSAIDs) and amantadine. Biocompatibility and anti‐inflammatory response of the gelator salts indicate their plausible use in biomedical applications (see figure). A simple strategy for designing salt-based supramolecular gelators comprised of various nonsteroidal anti-inflammatory drugs (NSAIDs) and amantadine (AMN) (an antiviral drug) has been demonstrated using a supramolecular synthon approach. Single-crystal and powder X-ray diffraction established the existence of the well-studied gel-forming 1D supramolecular synthon, namely, primary ammonium monocarboxylate (PAM) synthon in all the salts. Remarkably five out of six salts were found to be capable of gelling methyl salicylate (MS)-an important ingredient in commercially available topical gels; one such selected biocompatible salt displayed an anti-inflammatory response in prostaglandinE sub(2) (PGE sub(2)) assay, thereby indicating their plausible biomedical applications. A supramolecular synthon approach enables an easy access (through salt formation) to a series of supramolecular gelators derived from nonsteroidal anti-inflammatory drugs (NSAIDs) and amantadine. Biocompatibility and anti-inflammatory response of the gelator salts indicate their plausible use in biomedical applications (see figure). A simple strategy for designing salt-based supramolecular gelators comprised of various nonsteroidal anti-inflammatory drugs (NSAIDs) and amantadine (AMN) (an antiviral drug) has been demonstrated using a supramolecular synthon approach. Single-crystal and powder X-ray diffraction established the existence of the well-studied gel-forming 1D supramolecular synthon, namely, primary ammonium monocarboxylate (PAM) synthon in all the salts. Remarkably five out of six salts were found to be capable of gelling methyl salicylate (MS)-an important ingredient in commercially available topical gels; one such selected biocompatible salt displayed an anti-inflammatory response in prostaglandin E2 (PGE2 ) assay, thereby indicating their plausible biomedical applications. Abstract A simple strategy for designing salt‐based supramolecular gelators comprised of various nonsteroidal anti‐inflammatory drugs (NSAIDs) and amantadine (AMN) (an antiviral drug) has been demonstrated using a supramolecular synthon approach. Single‐crystal and powder X‐ray diffraction established the existence of the well‐studied gel‐forming 1D supramolecular synthon, namely, primary ammonium monocarboxylate (PAM) synthon in all the salts. Remarkably five out of six salts were found to be capable of gelling methyl salicylate (MS)—an important ingredient in commercially available topical gels; one such selected biocompatible salt displayed an anti‐inflammatory response in prostaglandin E 2 (PGE 2 ) assay, thereby indicating their plausible biomedical applications. A simple strategy for designing salt-based supramolecular gelators comprised of various nonsteroidal anti-inflammatory drugs (NSAIDs) and amantadine (AMN) (an antiviral drug) has been demonstrated using a supramolecular synthon approach. Single-crystal and powder X-ray diffraction established the existence of the well-studied gel-forming 1D supramolecular synthon, namely, primary ammonium monocarboxylate (PAM) synthon in all the salts. Remarkably five out of six salts were found to be capable of gelling methyl salicylate (MS)--an important ingredient in commercially available topical gels; one such selected biocompatible salt displayed an anti-inflammatory response in prostaglandinE2 (PGE2) assay, thereby indicating their plausible biomedical applications.
Author	Roy, Rajdip Jana, Siddhartha Sankar Dastidar, Parthasarathi Deb, Jolly
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Snippet	A simple strategy for designing salt‐based supramolecular gelators comprised of various nonsteroidal anti‐inflammatory drugs (NSAIDs) and amantadine (AMN) (an... A simple strategy for designing salt-based supramolecular gelators comprised of various nonsteroidal anti-inflammatory drugs (NSAIDs) and amantadine (AMN) (an... Abstract A simple strategy for designing salt‐based supramolecular gelators comprised of various nonsteroidal anti‐inflammatory drugs (NSAIDs) and amantadine...
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SubjectTerms	Amantadine Amantadine - chemistry Amantadine - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biocompatibility Biocompatible Materials - chemistry Cell Line Chemistry crystal engineering Diclofenac - chemistry Diclofenac - pharmacology Diffraction Dinoprostone - metabolism drug delivery Drug therapy Drugs Gels - chemistry Ingredients Interferon-gamma - pharmacology Lipopolysaccharides - toxicity LMWGS Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice Nonsteroidal anti-inflammatory drugs Rheology Salicylates Salicylates - chemistry Salts - chemistry Strategy supramolecular gels supramolecular synthons X-rays
Title	Exploiting Supramolecular Synthons in Designing Gelators Derived from Multiple Drugs
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