长链非编码RNA与妇科恶性肿瘤的相关性研究

近年来,曾经被认为是基因组转录＂噪音＂的长链非编码RNA（long non-coding RNA,lnc RNA）得到了学者们的广泛关注。lnc RNA是一类长度超过200个核苷酸（nt）的RNA,其本身并不编码蛋白,但其与生物信息学功能有着密切的联系,涉及表观遗传调控、细胞周期调控、m RNA降解、肿瘤耐药等多个方面,对肿瘤的发生、侵袭、转移、诊断及预后均起着至关重要的作用。同时,其在与激素以及P53信号通路的作用机制之间也有着一定的关系。学者们借助多种分子生物学研究方法,不断地对lnc RNA功能及其分子调控机制进行解析,发现肿瘤细胞与正常组织来源细胞间lnc RNA表达谱存在明显差异。而...

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Bibliographic Details
Published in国际妇产科学杂志 Vol. 42; no. 1; pp. 79 - 82
Main Author 尚春亮 姚书忠
Format Journal Article
LanguageChinese
Published 510080,中山大学附属第一医院妇产科 2015
Subjects
RNA
卵巢肿瘤
后成说,遗传
基因,p53
子宫内膜肿瘤
宫颈肿瘤
基因,p53
卵巢肿瘤
Genes,p53
RNA
Ovarian neoplasms
Uterine cervical neoplasms
宫颈肿瘤
子宫内膜肿瘤
后成说,遗传
Endometrial neoplasms
Epigenesis,genetic
Online AccessGet full text
ISSN1674-1870

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Summary:近年来,曾经被认为是基因组转录＂噪音＂的长链非编码RNA（long non-coding RNA,lnc RNA）得到了学者们的广泛关注。lnc RNA是一类长度超过200个核苷酸（nt）的RNA,其本身并不编码蛋白,但其与生物信息学功能有着密切的联系,涉及表观遗传调控、细胞周期调控、m RNA降解、肿瘤耐药等多个方面,对肿瘤的发生、侵袭、转移、诊断及预后均起着至关重要的作用。同时,其在与激素以及P53信号通路的作用机制之间也有着一定的关系。学者们借助多种分子生物学研究方法,不断地对lnc RNA功能及其分子调控机制进行解析,发现肿瘤细胞与正常组织来源细胞间lnc RNA表达谱存在明显差异。而且,lnc RNA的异常表达与多种恶性疾病的发生息息相关。lnc RNA与妇科肿瘤相关性的研究为妇科恶性肿瘤的诊断和治疗提供了一个新思路。
Bibliography:12-1399/R
RNA; Uterine cervical neoplasms; Ovarian neoplasms; Endometrial neoplasms; Epigenesis; genetic; Genes; p53
SHA NG Chun -liang, YAO Shu zhong.（ Departmentt of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China）
In recent years, the long non-coding RNA（lnc RNA） were thought to be the ＂noise＂ of genome transcription obtained the widespread attention. lnc RNAs are broadly defined as RNA molecules greater than 200 nt in length and do not encode proteins by themselves. But they have a close connection with the bioinformatics function, involving in epigenetic regulation, cell cycle, m RNA degradation, tumour drug resistance and other aspects. They play a critical role in the formation,development, erosion and metastasis of tumor, as well as diagnosis and prognosis of disease. At the same time, lnc RNAs have certain connections with the hormones and the P53 signaling pathway. With the aid of various molecular biology methods, we continue to parse the fun
ISSN:1674-1870