Carcinogenicity of "Non-Dioxinlike" Polychlorinated Biphenyls

• Published in: Critical reviews in toxicology Vol. 36; no. 9; pp. 663 - 694
• Main Authors: Knerr, Stefanie, Schrenk, Dieter
• Format: Journal Article
• Language: English
• Published: Colchester Informa UK Ltd 01.10.2006; Taylor & Francis; Informa Healthcare; Taylor & Francis Ltd
• Subjects: Animals; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Carcinogenicity; Carcinogenicity Tests; Carcinogens, Environmental - toxicity; Chemical agents; Cocarcinogenesis; Dose-Response Relationship, Drug; Female; Humans; Kidney Neoplasms - chemically induced; Kidney Neoplasms - pathology; Liver Neoplasms - chemically induced; Liver Neoplasms - pathology; Liver Tumors; Male; Medical sciences; Mice; Occupational Exposure; Polychlorinated Biphenyls; Polychlorinated Biphenyls - toxicity; Rats; Rodent Models; Tumor Promotion; Tumors; Human; Animal model; Tumor promotor; Rodentia; Tumorigenicity; Polychlorinated Biphenyls; Review; Polychlorobiphenyl; Epidemiology; Rodent Models; Carcinogen; Vertebrata; Liver Tumors; Mammalia; Tumor Promotion; Liver tumor; Carcinogenicity

Complex technical mixtures of polychlorinated biphenyls (PCBs) cause liver and thyroid neoplasms in rodents, whereas very few data are available on the carcinogenic potency of single non-dioxinlike (NDL) PCB congeners. In most genotoxicity assays technical PCB mixtures and individual congeners were...