Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

Fernando Rivadeneira and colleagues report findings from a large-scale meta-analysis of genome-wide association studies for bone mineral density. The loci identified in this study map to genes in signaling pathways relevant to bone metabolism and highlight the complex genetic architecture underlying...

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Published inNature genetics Vol. 41; no. 11; pp. 1199 - 1206
Main Authors RIVADENEIRA, Fernando, STYRKARSDOTTIR, Unnur, CUPPLES, L. Adrienne, DELOUKAS, Panagiotis, DEMISSIE, Serkalem, GRUNDBERG, Elin, HOFMAN, Albert, KONG, Augustine, KARASIK, David, VAN MEURS, Joyce B, OOSTRA, Ben, PASTINEN, Tomi, ESTRADA, Karol, POLS, Huibert A. P, SIGURDSSON, Gunnar, SORANZO, Nicole, THORLEIFSSON, Gudmar, THORSTEINSDOTTIR, Unnur, WILLIAMS, Frances M. K, WILSON, Scott G, YANHUA ZHOU, RALSTON, Stuart H, VAN DUIJN, Cornelia M, HALLDORSSON, Bjarni V, SPECTOR, Timothy, KIEL, Douglas P, STEFANSSON, Kari, IOANNIDIS, John P. A, UITTERLINDEN, André G, HSU, Yi-Hsiang, RICHARDS, J. Brent, ZILLIKENS, M. Carola, KAWOURA, Fotini K, AMIN, Najaf, AULCHENKO, Yurii S
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.11.2009
Nature Publishing Group
Subjects
Agriculture
Animal Genetics and Genomics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Bone Density - genetics
Bone mineral density
Bones
Cancer Research
Clinical medicine
Complications and side effects
Density
Femur - physiology
Fractures
Fractures, Bone - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Gene Function
Genes
Genetic aspects
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genome-Wide Association Study
Genotype
Human Genetics
Humans
Lumbar Vertebrae - physiology
Medical research
Meta-analysis
Osteoporosis
Physiological aspects
Polymorphism, Single Nucleotide
Quality control
Quantitative Trait Loci
Risk Factors
Single nucleotide polymorphisms
Spine
White People - genetics
United States
Netherlands
Iceland
Osteoarticular system
Association
Bone
Locus
Density
Metaanalysis
Online AccessGet full text

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Abstract Fernando Rivadeneira and colleagues report findings from a large-scale meta-analysis of genome-wide association studies for bone mineral density. The loci identified in this study map to genes in signaling pathways relevant to bone metabolism and highlight the complex genetic architecture underlying osteoporosis. Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 × 10 −8 ), of which 13 map to regions not previously associated with this trait: 1p31.3 ( GPR177 ), 2p21 ( SPTBN1 ), 3p22 ( CTNNB1 ), 4q21.1 ( MEPE ), 5q14 ( MEF2C ), 7p14 ( STARD3NL ), 7q21.3 ( FLJ42280 ), 11p11.2 ( LRP4 , ARHGAP1 , F2 ), 11p14.1 ( DCDC5 ), 11p15 ( SOX6 ), 16q24 ( FOXL1 ), 17q21 ( HDAC5 ) and 17q12 ( CRHR1 ). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 ( ZBTB40 ), 6q25 ( ESR1 ), 8q24 ( TNFRSF11B ), 11q13.4 ( LRP5 ), 12q13 ( SP7 ), 13q14 ( TNFSF11 ) and 18q21 ( TNFRSF11A ). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD.
AbstractList Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 x [10.sup.-8]), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 CTNNB1), 4q21.1 (MEPE), 5q14 (MEF2C), 7p14 (STARD3NL), 7q21.3 (FLJ42280), 11p11.2 (LRP4, ARHGAP1, F2), 11p14.1 DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 (ZBTB40), 6q25 (ESR1), 8q24 (TNFRSF11B), 11q13.4 (LRP5), 12q13 (SP7), 13q14 (TNFSF11) and 18q21 (TNFRSF11A). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD.
Fernando Rivadeneira and colleagues report findings from a large-scale meta-analysis of genome-wide association studies for bone mineral density. The loci identified in this study map to genes in signaling pathways relevant to bone metabolism and highlight the complex genetic architecture underlying osteoporosis. Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 × 10 −8 ), of which 13 map to regions not previously associated with this trait: 1p31.3 ( GPR177 ), 2p21 ( SPTBN1 ), 3p22 ( CTNNB1 ), 4q21.1 ( MEPE ), 5q14 ( MEF2C ), 7p14 ( STARD3NL ), 7q21.3 ( FLJ42280 ), 11p11.2 ( LRP4 , ARHGAP1 , F2 ), 11p14.1 ( DCDC5 ), 11p15 ( SOX6 ), 16q24 ( FOXL1 ), 17q21 ( HDAC5 ) and 17q12 ( CRHR1 ). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 ( ZBTB40 ), 6q25 ( ESR1 ), 8q24 ( TNFRSF11B ), 11q13.4 ( LRP5 ), 12q13 ( SP7 ), 13q14 ( TNFSF11 ) and 18q21 ( TNFRSF11A ). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD.
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 x 10(-8)), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 (CTNNB1), 4q21.1 (MEPE), 5q14 (MEF2C), 7p14 (STARD3NL), 7q21.3 (FLJ42280), 11p11.2 (LRP4, ARHGAP1, F2), 11p14.1 (DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 (ZBTB40), 6q25 (ESR1), 8q24 (TNFRSF11B), 11q13.4 (LRP5), 12q13 (SP7), 13q14 (TNFSF11) and 18q21 (TNFRSF11A). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD.
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 10 super(-8)), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 (CTNNB1), 4q21.1 (MEPE), 5q14 (MEF2C), 7p14 (STARD3NL), 7q21.3 (FLJ42280), 11p11.2 (LRP4, ARHGAP1, F2), 11p14.1 (DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 (ZBTB40), 6q25 (ESR1), 8q24 (TNFRSF11B), 11q13.4 (LRP5), 12q13 (SP7), 13q14 (TNFSF11) and 18q21 (TNFRSF11A). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD.
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 x 10(-8)), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 (CTNNB1), 4q21.1 (MEPE), 5q14 (MEF2C), 7p14 (STARD3NL), 7q21.3 (FLJ42280), 11p11.2 (LRP4, ARHGAP1, F2), 11p14.1 (DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 (ZBTB40), 6q25 (ESR1), 8q24 (TNFRSF11B), 11q13.4 (LRP5), 12q13 (SP7), 13q14 (TNFSF11) and 18q21 (TNFRSF11A). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD.Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 x 10(-8)), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 (CTNNB1), 4q21.1 (MEPE), 5q14 (MEF2C), 7p14 (STARD3NL), 7q21.3 (FLJ42280), 11p11.2 (LRP4, ARHGAP1, F2), 11p14.1 (DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 (ZBTB40), 6q25 (ESR1), 8q24 (TNFRSF11B), 11q13.4 (LRP5), 12q13 (SP7), 13q14 (TNFSF11) and 18q21 (TNFRSF11A). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD.
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 loci reaching genome-wide significance (GWS; P<5×10 −8 ), of which 13 map to new regions including 1p31.3 ( GPR177 ), 2p21 ( SPTBN1 ), 3p22 ( CTNNB1 ), 4q21.1 ( MEPE ), 5q14 ( MEF2C ), 7p14 ( STARD3NL ), 7q21.3 ( FLJ42280 ), 11p11.2 ( LRP4 ; ARHGAP1 ; F2 ), 11p14.1 ( DCDC5 ), 11p15 ( SOX6 ), 16q24 ( FOXL1 ), 17q21 ( HDAC5 ) and 17q12 ( CRHR1 ). The metaanalysis also confirmed at GWS level, seven known BMD loci on 1p36 ( ZBTB40 ), 6q25 ( ESR1 ), 8q24 ( TNFRSF11B ), 11q13.4 ( LRP5 ), 12q13 ( SP7 ), 13q14 ( TNFSF11 ), and 18q21 ( TNFRSF11A ). The numerous SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism, and highlight the complex genetic architecture underlying osteoporosis and BMD variation.
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 × 10^sup -8^), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 (CTNNB1), 4q21.1 (MEPE), 5q14 (MEF2C), 7p14 (STARD3NL), 7q21.3 (FLJ42280), 11p11.2 (LRP4, ARHGAP1, F2), 11p14.1 (DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 (ZBTB40), 6q25 (ESR1), 8q24 (TNFRSF11B), 11q13.4 (LRP5), 12q13 (SP7), 13q14 (TNFSF11) and 18q21 (TNFRSF11A). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD. [PUBLICATION ABSTRACT]
Audience Academic
Author DEMISSIE, Serkalem
GRUNDBERG, Elin
STEFANSSON, Kari
STYRKARSDOTTIR, Unnur
SIGURDSSON, Gunnar
KAWOURA, Fotini K
RIVADENEIRA, Fernando
KARASIK, David
HOFMAN, Albert
HSU, Yi-Hsiang
RICHARDS, J. Brent
VAN MEURS, Joyce B
PASTINEN, Tomi
THORLEIFSSON, Gudmar
HALLDORSSON, Bjarni V
DELOUKAS, Panagiotis
ZILLIKENS, M. Carola
ESTRADA, Karol
WILLIAMS, Frances M. K
RALSTON, Stuart H
AMIN, Najaf
SORANZO, Nicole
VAN DUIJN, Cornelia M
UITTERLINDEN, André G
KIEL, Douglas P
POLS, Huibert A. P
KONG, Augustine
WILSON, Scott G
THORSTEINSDOTTIR, Unnur
CUPPLES, L. Adrienne
OOSTRA, Ben
AULCHENKO, Yurii S
IOANNIDIS, John P. A
YANHUA ZHOU
SPECTOR, Timothy
AuthorAffiliation 2 Department of Epidemiology, Erasmus MC, Rotterdam, 3015GE, The Netherlands
10 Department of Biostatistics, School of Public Health, Boston University, Boston, MA, 02118 USA
16 School of Medicine & Pharmacology, The University of Western Australia and Department of Endocrinology & Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia
1 Department of Internal Medicine, Erasmus MC, Rotterdam, 3015GE, The Netherlands
15 Department of Endocrinology and Metabolism, University Hospital, 108 Reykjavik, Iceland
9 Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
3 deCODE Genetics, 101 Reykjavík, Iceland
18 Center for Genetic Epidemiology and Modeling, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
4 Reykjavik University, 103 Reykjavik, Iceland
14 Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland
17 Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, Western Genera
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Cites_doi 10.1002/jbmr.5650110414
10.1038/ng0508-489
10.1038/ng.287
10.1007/BF00145007
10.1016/j.bbrc.2009.06.071
10.1007/s10654-009-9386-z
10.1359/jbmr.2001.16.10.1765
10.1359/JBMR.050813
10.1093/bioinformatics/btm108
10.1359/jbmr.060605
10.1038/nrg2344
10.1093/aje/kwm021
10.1016/j.bone.2005.11.017
10.1038/sj.onc.1206406
10.1152/physiolgenomics.00028.2008
10.1073/pnas.0605170103
10.1002/gepi.20303
10.1359/jbmr.060810
10.1001/jama.299.11.1277
10.1016/j.devcel.2005.02.017
10.1016/j.ajhg.2009.05.005
10.1038/nrg2544
10.1084/jem.20071294
10.1016/S1471-4914(03)00030-3
10.1056/NEJMoa0801197
10.1371/journal.pmed.0030090
10.1038/ng.357
10.1016/j.bone.2003.10.001
10.1359/jbmr.060806
10.1111/j.1749-6632.1963.tb13299.x
10.1126/science.1075994
10.1073/pnas.0609149104
10.1016/j.cell.2006.02.049
10.1038/ng2088
10.1086/519795
10.1038/ng.122
10.1007/s00223-005-0127-3
10.1038/ng786
10.1016/j.bone.2007.11.007
10.1016/S0140-6736(08)60599-1
10.1073/pnas.96.14.8156
10.1016/j.cytogfr.2004.06.004
10.1371/journal.pmed.0020124
10.1093/hmg/ddn288
10.7326/0003-4819-145-4-200608150-00005
10.1111/j.0006-341X.1999.00997.x
10.1172/JCI31960
10.1186/1471-2164-7-188
10.1038/nature06258
10.1016/S1534-5807(01)00003-X
10.1001/jama.292.17.2105
10.1101/gad.11.7.926
10.1038/sj.ejhg.5201188
10.1038/ng.284
10.1038/35040593
10.1093/oxfordjournals.aje.a112813
10.1210/edrv.23.3.0464
10.1093/nar/gkl679
10.1359/JBMR.050611
10.1038/ng.121
10.1007/s10654-008-9302-y
10.1038/ng1847
10.1007/BF01623275
10.1038/sj.emboj.7600729
10.1007/BF01623782
10.1074/jbc.M203250200
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Association
Bone
Locus
Density
Metaanalysis
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References Nifuji, Miura, Kato, Kellermann, Noda (CR34) 2001; 16
Rivadeneira (CR71) 2006; 21
Ellies (CR1) 2006; 21
Zhou (CR31) 2006; 103
Malaval (CR40) 2008; 205
Grundberg (CR69) 2008; 33
Bänziger (CR25) 2006; 125
Styrkarsdottir (CR12) 2009; 41
Weedon (CR17) 2008; 40
Winnier, Hargett, Hogan (CR35) 1997; 11
Styrkarsdottir (CR13) 2008; 358
Gudbjartsson (CR18) 2008; 40
Wang, Yang, Debidda, Witte, Zheng (CR43) 2007; 104
Ioannidis (CR6) 2004; 292
McKinsey, Zhang, Lu, Olson (CR44) 2000; 408
Price (CR57) 2006; 38
Meyers, Zayzafoon, Douglas, McDonald (CR42) 2005; 20
Ioannidis (CR3) 2007; 22
Kang, Alliston, Delston, Derynck (CR46) 2005; 24
Schuit (CR72) 2004; 34
Alford, Hankenson (CR38) 2006; 38
Smits (CR30) 2001; 1
Kim (CR33) 2009; 386
van Meurs (CR10) 2008; 299
Dawber, Kannel, Lyell (CR54) 1963; 107
Marchini, Howie, Myers, McVean, Donnelly (CR60) 2007; 39
Peacock, Turner, Econs, Foroud (CR16) 2002; 23
Yoshitake, Rittling, Denhardt, Noda (CR41) 1999; 96
Kanis, Delmas, Burckhardt, Cooper, Torgerson (CR14) 1997; 7
CR49
CR48
Cho (CR29) 2009; 41
Uitterlinden (CR9) 2006; 145
Stankiewicz (CR36) 2009; 84
Kutyavin (CR61) 2006; 34
de Bakker (CR67) 2008; 17
Reiner (CR32) 2006; 7
Frazer (CR23) 2007; 449
Little (CR62) 2009; 24
Schroeder, Westendorf (CR45) 2005; 20
Aulchenko, Ripke, Isaacs, van Duijn (CR65) 2007; 23
Richards (CR24) 2008; 371
Theoleyre (CR2) 2004; 15
Langdahl (CR7) 2008; 42
Splansky (CR56) 2007; 165
Potthoff (CR28) 2007; 117
Tang (CR37) 2003; 299
Devlin, Roeder (CR20) 1999; 55
Ioannidis, Thomas, Daly (CR47) 2009; 10
McCloskey (CR73) 1993; 3
CR58
Ioannidis (CR4) 2005; 2
Gowen (CR39) 2003; 278
Blake, Knapp, Spector, Fogelman (CR15) 2006; 78
Pe'er, Yelensky, Altshuler, Daly (CR22) 2008; 32
Hofman (CR50) 2009; 24
Willer (CR21) 2009; 41
Aulchenko (CR52) 2004; 12
Arden, Baker, Hogg, Baan, Spector (CR53) 1996; 11
Abecasis, Cherny, Cookson, Cardon (CR63) 2002; 30
Matsuda (CR26) 2003; 22
Hofman, Grobbee, de Jong, van den Ouweland (CR51) 1991; 7
Purcell (CR70) 2007; 81
Visscher (CR19) 2008; 40
CR68
Glass (CR27) 2005; 8
CR66
CR64
Kannel, Feinleib, McNamara, Garrison, Castelli (CR55) 1979; 110
Ioannidis (CR5) 2003; 9
Ralston (CR8) 2006; 3
McCarthy (CR11) 2008; 9
Li, Abecasis (CR59) 2006; S79
GM Blake (BFng446_CR15) 2006; 78
TR Dawber (BFng446_CR54) 1963; 107
Y Li (BFng446_CR59) 2006; S79
IV Kutyavin (BFng446_CR61) 2006; 34
S Purcell (BFng446_CR70) 2007; 81
BL Langdahl (BFng446_CR7) 2008; 42
AI Alford (BFng446_CR38) 2006; 38
SC Schuit (BFng446_CR72) 2004; 34
U Styrkarsdottir (BFng446_CR13) 2008; 358
JA Kanis (BFng446_CR14) 1997; 7
MN Weedon (BFng446_CR17) 2008; 40
G Zhou (BFng446_CR31) 2006; 103
VE Meyers (BFng446_CR42) 2005; 20
MI McCarthy (BFng446_CR11) 2008; 9
TM Schroeder (BFng446_CR45) 2005; 20
KA Frazer (BFng446_CR23) 2007; 449
EV McCloskey (BFng446_CR73) 1993; 3
JB Richards (BFng446_CR24) 2008; 371
A Hofman (BFng446_CR50) 2009; 24
SH Ralston (BFng446_CR8) 2006; 3
L Malaval (BFng446_CR40) 2008; 205
M Peacock (BFng446_CR16) 2002; 23
YS Cho (BFng446_CR29) 2009; 41
GL Splansky (BFng446_CR56) 2007; 165
Y Tang (BFng446_CR37) 2003; 299
U Styrkarsdottir (BFng446_CR12) 2009; 41
GR Abecasis (BFng446_CR63) 2002; 30
DL Ellies (BFng446_CR1) 2006; 21
A Hofman (BFng446_CR51) 1991; 7
JB van Meurs (BFng446_CR10) 2008; 299
L Wang (BFng446_CR43) 2007; 104
DA Glass II (BFng446_CR27) 2005; 8
JP Ioannidis (BFng446_CR6) 2004; 292
WB Kannel (BFng446_CR55) 1979; 110
BFng446_CR68
BFng446_CR66
C Bänziger (BFng446_CR25) 2006; 125
I Pe'er (BFng446_CR22) 2008; 32
SH Kim (BFng446_CR33) 2009; 386
BFng446_CR64
JP Ioannidis (BFng446_CR5) 2003; 9
P Smits (BFng446_CR30) 2001; 1
DF Gudbjartsson (BFng446_CR18) 2008; 40
JS Kang (BFng446_CR46) 2005; 24
JP Ioannidis (BFng446_CR47) 2009; 10
JP Ioannidis (BFng446_CR4) 2005; 2
YS Aulchenko (BFng446_CR65) 2007; 23
O Reiner (BFng446_CR32) 2006; 7
MJ Potthoff (BFng446_CR28) 2007; 117
BFng446_CR58
J Little (BFng446_CR62) 2009; 24
AL Price (BFng446_CR57) 2006; 38
J Marchini (BFng446_CR60) 2007; 39
S Theoleyre (BFng446_CR2) 2004; 15
LC Gowen (BFng446_CR39) 2003; 278
F Rivadeneira (BFng446_CR71) 2006; 21
E Grundberg (BFng446_CR69) 2008; 33
CJ Willer (BFng446_CR21) 2009; 41
H Yoshitake (BFng446_CR41) 1999; 96
JP Ioannidis (BFng446_CR3) 2007; 22
GE Winnier (BFng446_CR35) 1997; 11
BFng446_CR49
YS Aulchenko (BFng446_CR52) 2004; 12
B Devlin (BFng446_CR20) 1999; 55
A Nifuji (BFng446_CR34) 2001; 16
BFng446_CR48
P Stankiewicz (BFng446_CR36) 2009; 84
AG Uitterlinden (BFng446_CR9) 2006; 145
NK Arden (BFng446_CR53) 1996; 11
TA McKinsey (BFng446_CR44) 2000; 408
PM Visscher (BFng446_CR19) 2008; 40
A Matsuda (BFng446_CR26) 2003; 22
PI de Bakker (BFng446_CR67) 2008; 17
References_xml – volume: 11
  start-page: 530
  year: 1996
  end-page: 534
  ident: CR53
  article-title: The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins
  publication-title: J. Bone Miner. Res.
  doi: 10.1002/jbmr.5650110414
– volume: 40
  start-page: 489
  year: 2008
  end-page: 490
  ident: CR19
  article-title: Sizing up human height variation
  publication-title: Nat. Genet.
  doi: 10.1038/ng0508-489
– volume: 41
  start-page: 25
  year: 2009
  end-page: 34
  ident: CR21
  article-title: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
  publication-title: Nat. Genet.
  doi: 10.1038/ng.287
– volume: 7
  start-page: 403
  year: 1991
  end-page: 422
  ident: CR51
  article-title: Determinants of disease and disability in the elderly: the Rotterdam Elderly Study
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/BF00145007
– volume: 386
  start-page: 532
  year: 2009
  end-page: 536
  ident: CR33
  article-title: The forkhead transcription factor Foxc2 stimulates osteoblast differentiation
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2009.06.071
– ident: CR49
– ident: CR68
– volume: 24
  start-page: 553
  year: 2009
  end-page: 572
  ident: CR50
  article-title: The Rotterdam Study: 2010 objectives and design update
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-009-9386-z
– volume: 16
  start-page: 1765
  year: 2001
  end-page: 1771
  ident: CR34
  article-title: Bone morphogenetic protein regulation of forkhead/winged helix transcription factor Foxc2 (Mfh1) in a murine mesodermal cell line C1 and in skeletal precursor cells
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.2001.16.10.1765
– volume: 20
  start-page: 2254
  year: 2005
  end-page: 2263
  ident: CR45
  article-title: Histone deacetylase inhibitors promote osteoblast maturation
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/JBMR.050813
– volume: 23
  start-page: 1294
  year: 2007
  end-page: 1296
  ident: CR65
  article-title: GenABEL: an R library for genome-wide association analysis
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btm108
– volume: 21
  start-page: 1443
  year: 2006
  end-page: 1456
  ident: CR71
  article-title: Estrogen receptor beta ( ) polymorphisms in interaction with estrogen receptor alpha ( ) and insulin-like growth factor I ( ) variants influence the risk of fracture in postmenopausal women
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.060605
– volume: 9
  start-page: 356
  year: 2008
  end-page: 369
  ident: CR11
  article-title: Genome-wide association studies for complex traits: consensus, uncertainty and challenges
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2344
– ident: CR58
– volume: 165
  start-page: 1328
  year: 2007
  end-page: 1335
  ident: CR56
  article-title: The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/aje/kwm021
– volume: 38
  start-page: 749
  year: 2006
  end-page: 757
  ident: CR38
  article-title: Matricellular proteins: extracellular modulators of bone development, remodeling, and regeneration
  publication-title: Bone
  doi: 10.1016/j.bone.2005.11.017
– volume: 22
  start-page: 3307
  year: 2003
  end-page: 3318
  ident: CR26
  article-title: Large-scale identification and characterization of human genes that activate NF-κB and MAPK signaling pathways
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1206406
– volume: 33
  start-page: 301
  year: 2008
  end-page: 311
  ident: CR69
  article-title: Systematic assessment of the human osteoblast transcriptome in resting and induced primary cells
  publication-title: Physiol. Genomics
  doi: 10.1152/physiolgenomics.00028.2008
– volume: 103
  start-page: 19004
  year: 2006
  end-page: 19009
  ident: CR31
  article-title: Dominance of SOX9 function over RUNX2 during skeletogenesis
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0605170103
– volume: 32
  start-page: 381
  year: 2008
  end-page: 385
  ident: CR22
  article-title: Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
  publication-title: Genet. Epidemiol.
  doi: 10.1002/gepi.20303
– volume: 21
  start-page: 1738
  year: 2006
  end-page: 1749
  ident: CR1
  article-title: Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.060810
– volume: 299
  start-page: 1277
  year: 2008
  end-page: 1290
  ident: CR10
  article-title: Large-scale analysis of association between and variants and osteoporosis
  publication-title: J. Am. Med. Assoc.
  doi: 10.1001/jama.299.11.1277
– volume: 8
  start-page: 751
  year: 2005
  end-page: 764
  ident: CR27
  article-title: Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2005.02.017
– volume: 84
  start-page: 780
  year: 2009
  end-page: 791
  ident: CR36
  article-title: Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of cause alveolar capillary dysplasia and other malformations
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2009.05.005
– volume: 10
  start-page: 318
  year: 2009
  end-page: 329
  ident: CR47
  article-title: Validating, augmenting and refining genome-wide association signals
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2544
– volume: 205
  start-page: 1145
  year: 2008
  end-page: 1153
  ident: CR40
  article-title: Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20071294
– volume: 9
  start-page: 135
  year: 2003
  end-page: 138
  ident: CR5
  article-title: Genetic associations: false or true?
  publication-title: Trends Mol. Med.
  doi: 10.1016/S1471-4914(03)00030-3
– volume: 358
  start-page: 2355
  year: 2008
  end-page: 2365
  ident: CR13
  article-title: Multiple genetic loci for bone mineral density and fractures
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0801197
– volume: 3
  start-page: e90
  year: 2006
  ident: CR8
  article-title: Large-scale evidence for the effect of the Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.0030090
– volume: 41
  start-page: 527
  year: 2009
  end-page: 534
  ident: CR29
  article-title: A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
  publication-title: Nat. Genet.
  doi: 10.1038/ng.357
– volume: 34
  start-page: 195
  year: 2004
  end-page: 202
  ident: CR72
  article-title: Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study
  publication-title: Bone
  doi: 10.1016/j.bone.2003.10.001
– volume: 22
  start-page: 173
  year: 2007
  end-page: 183
  ident: CR3
  article-title: Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.060806
– volume: 107
  start-page: 539
  year: 1963
  end-page: 556
  ident: CR54
  article-title: An approach to longitudinal studies in a community: the Framingham Study
  publication-title: Ann. NY Acad. Sci.
  doi: 10.1111/j.1749-6632.1963.tb13299.x
– ident: CR64
– volume: 299
  start-page: 574
  year: 2003
  end-page: 577
  ident: CR37
  article-title: Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice
  publication-title: Science
  doi: 10.1126/science.1075994
– volume: 104
  start-page: 1248
  year: 2007
  end-page: 1253
  ident: CR43
  article-title: Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0609149104
– volume: 125
  start-page: 509
  year: 2006
  end-page: 522
  ident: CR25
  article-title: Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells
  publication-title: Cell
  doi: 10.1016/j.cell.2006.02.049
– ident: CR66
– volume: 39
  start-page: 906
  year: 2007
  end-page: 913
  ident: CR60
  article-title: A new multipoint method for genome-wide association studies by imputation of genotypes
  publication-title: Nat. Genet.
  doi: 10.1038/ng2088
– volume: 81
  start-page: 559
  year: 2007
  end-page: 575
  ident: CR70
  article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/519795
– volume: 40
  start-page: 609
  year: 2008
  end-page: 615
  ident: CR18
  article-title: Many sequence variants affecting diversity of adult human height
  publication-title: Nat. Genet.
  doi: 10.1038/ng.122
– volume: 78
  start-page: 9
  year: 2006
  end-page: 17
  ident: CR15
  article-title: Predicting the risk of fracture at any site in the skeleton: are all bone mineral density measurement sites equally effective?
  publication-title: Calcif. Tissue Int.
  doi: 10.1007/s00223-005-0127-3
– volume: 30
  start-page: 97
  year: 2002
  end-page: 101
  ident: CR63
  article-title: Merlin–rapid analysis of dense genetic maps using sparse gene flow trees
  publication-title: Nat. Genet.
  doi: 10.1038/ng786
– volume: 42
  start-page: 969
  year: 2008
  end-page: 981
  ident: CR7
  article-title: Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene ( ) and osteoporosis: the GENOMOS study
  publication-title: Bone
  doi: 10.1016/j.bone.2007.11.007
– volume: 371
  start-page: 1505
  year: 2008
  end-page: 1512
  ident: CR24
  article-title: Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
  publication-title: Lancet
  doi: 10.1016/S0140-6736(08)60599-1
– volume: 96
  start-page: 8156
  year: 1999
  end-page: 8160
  ident: CR41
  article-title: Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.96.14.8156
– volume: 15
  start-page: 457
  year: 2004
  end-page: 475
  ident: CR2
  article-title: The molecular triad Opg/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2004.06.004
– volume: 2
  start-page: e124
  year: 2005
  ident: CR4
  article-title: Why most published research findings are false
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.0020124
– volume: 17
  start-page: R122
  year: 2008
  end-page: R128
  ident: CR67
  article-title: Practical aspects of imputation-driven meta-analysis of genome-wide association studies
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddn288
– volume: 145
  start-page: 255
  year: 2006
  end-page: 264
  ident: CR9
  article-title: The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis
  publication-title: Ann. Intern. Med.
  doi: 10.7326/0003-4819-145-4-200608150-00005
– volume: 55
  start-page: 997
  year: 1999
  end-page: 1004
  ident: CR20
  article-title: Genomic control for association studies
  publication-title: Biometrics
  doi: 10.1111/j.0006-341X.1999.00997.x
– volume: 117
  start-page: 2459
  year: 2007
  end-page: 2467
  ident: CR28
  article-title: Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI31960
– volume: 7
  start-page: 188
  year: 2006
  ident: CR32
  article-title: The evolving doublecortin (DCX) superfamily
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-7-188
– volume: 449
  start-page: 851
  year: 2007
  end-page: 861
  ident: CR23
  article-title: A second generation human haplotype map of over 3.1 million SNPs
  publication-title: Nature
  doi: 10.1038/nature06258
– ident: CR48
– volume: 1
  start-page: 277
  year: 2001
  end-page: 290
  ident: CR30
  article-title: The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(01)00003-X
– volume: 292
  start-page: 2105
  year: 2004
  end-page: 2114
  ident: CR6
  article-title: Differential genetic effects of gene polymorphisms on osteoporosis outcomes
  publication-title: J. Am. Med. Assoc.
  doi: 10.1001/jama.292.17.2105
– volume: S79
  start-page: 2290
  year: 2006
  ident: CR59
  article-title: Mach 1.0: rapid haplotype reconstruction and missing genotype inference
  publication-title: Am. J. Hum. Genet.
– volume: 11
  start-page: 926
  year: 1997
  end-page: 940
  ident: CR35
  article-title: The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo
  publication-title: Genes Dev.
  doi: 10.1101/gad.11.7.926
– volume: 12
  start-page: 527
  year: 2004
  end-page: 534
  ident: CR52
  article-title: Linkage disequilibrium in young genetically isolated Dutch population
  publication-title: Eur. J. Hum. Genet.
  doi: 10.1038/sj.ejhg.5201188
– volume: 41
  start-page: 15
  year: 2009
  end-page: 17
  ident: CR12
  article-title: New sequence variants associated with bone mineral density
  publication-title: Nat. Genet.
  doi: 10.1038/ng.284
– volume: 408
  start-page: 106
  year: 2000
  end-page: 111
  ident: CR44
  article-title: Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
  publication-title: Nature
  doi: 10.1038/35040593
– volume: 110
  start-page: 281
  year: 1979
  end-page: 290
  ident: CR55
  article-title: An investigation of coronary heart disease in families. The Framingham offspring study
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/oxfordjournals.aje.a112813
– volume: 23
  start-page: 303
  year: 2002
  end-page: 326
  ident: CR16
  article-title: Genetics of osteoporosis
  publication-title: Endocr. Rev.
  doi: 10.1210/edrv.23.3.0464
– volume: 34
  start-page: e128
  year: 2006
  ident: CR61
  article-title: A novel endonuclease IV post-PCR genotyping system
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkl679
– volume: 20
  start-page: 1858
  year: 2005
  end-page: 1866
  ident: CR42
  article-title: RhoA and cytoskeletal disruption mediate reduced osteoblastogenesis and enhanced adipogenesis of human mesenchymal stem cells in modeled microgravity
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/JBMR.050611
– volume: 40
  start-page: 575
  year: 2008
  end-page: 583
  ident: CR17
  article-title: Genome-wide association analysis identifies 20 loci that influence adult height
  publication-title: Nat. Genet.
  doi: 10.1038/ng.121
– volume: 24
  start-page: 37
  year: 2009
  end-page: 55
  ident: CR62
  article-title: Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-008-9302-y
– volume: 38
  start-page: 904
  year: 2006
  end-page: 909
  ident: CR57
  article-title: Principal components analysis corrects for stratification in genome-wide association studies
  publication-title: Nat. Genet.
  doi: 10.1038/ng1847
– volume: 3
  start-page: 138
  year: 1993
  end-page: 147
  ident: CR73
  article-title: The assessment of vertebral deformity: a method for use in population studies and clinical trials
  publication-title: Osteoporos. Int.
  doi: 10.1007/BF01623275
– volume: 24
  start-page: 2543
  year: 2005
  end-page: 2555
  ident: CR46
  article-title: Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600729
– volume: 7
  start-page: 390
  year: 1997
  end-page: 406
  ident: CR14
  article-title: Guidelines for diagnosis and management of osteoporosis. The European Foundation for Osteoporosis and Bone Disease
  publication-title: Osteoporos. Int.
  doi: 10.1007/BF01623782
– volume: 278
  start-page: 1998
  year: 2003
  end-page: 2007
  ident: CR39
  article-title: Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M203250200
– volume: 34
  start-page: e128
  year: 2006
  ident: BFng446_CR61
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkl679
– volume: 23
  start-page: 303
  year: 2002
  ident: BFng446_CR16
  publication-title: Endocr. Rev.
  doi: 10.1210/edrv.23.3.0464
– volume: 1
  start-page: 277
  year: 2001
  ident: BFng446_CR30
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(01)00003-X
– volume: 16
  start-page: 1765
  year: 2001
  ident: BFng446_CR34
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.2001.16.10.1765
– volume: 3
  start-page: 138
  year: 1993
  ident: BFng446_CR73
  publication-title: Osteoporos. Int.
  doi: 10.1007/BF01623275
– volume: 107
  start-page: 539
  year: 1963
  ident: BFng446_CR54
  publication-title: Ann. NY Acad. Sci.
  doi: 10.1111/j.1749-6632.1963.tb13299.x
– volume: 41
  start-page: 25
  year: 2009
  ident: BFng446_CR21
  publication-title: Nat. Genet.
  doi: 10.1038/ng.287
– volume: 42
  start-page: 969
  year: 2008
  ident: BFng446_CR7
  publication-title: Bone
  doi: 10.1016/j.bone.2007.11.007
– volume: 55
  start-page: 997
  year: 1999
  ident: BFng446_CR20
  publication-title: Biometrics
  doi: 10.1111/j.0006-341X.1999.00997.x
– volume: 20
  start-page: 2254
  year: 2005
  ident: BFng446_CR45
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/JBMR.050813
– ident: BFng446_CR49
– volume: 41
  start-page: 15
  year: 2009
  ident: BFng446_CR12
  publication-title: Nat. Genet.
  doi: 10.1038/ng.284
– volume: 205
  start-page: 1145
  year: 2008
  ident: BFng446_CR40
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20071294
– volume: 24
  start-page: 553
  year: 2009
  ident: BFng446_CR50
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-009-9386-z
– ident: BFng446_CR64
– volume: 8
  start-page: 751
  year: 2005
  ident: BFng446_CR27
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2005.02.017
– volume: 23
  start-page: 1294
  year: 2007
  ident: BFng446_CR65
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btm108
– volume: 278
  start-page: 1998
  year: 2003
  ident: BFng446_CR39
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M203250200
– ident: BFng446_CR68
– volume: 21
  start-page: 1443
  year: 2006
  ident: BFng446_CR71
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.060605
– volume: 358
  start-page: 2355
  year: 2008
  ident: BFng446_CR13
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0801197
– ident: BFng446_CR58
  doi: 10.1038/nature06258
– volume: 15
  start-page: 457
  year: 2004
  ident: BFng446_CR2
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2004.06.004
– volume: 103
  start-page: 19004
  year: 2006
  ident: BFng446_CR31
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0605170103
– volume: 40
  start-page: 575
  year: 2008
  ident: BFng446_CR17
  publication-title: Nat. Genet.
  doi: 10.1038/ng.121
– volume: 41
  start-page: 527
  year: 2009
  ident: BFng446_CR29
  publication-title: Nat. Genet.
  doi: 10.1038/ng.357
– volume: 38
  start-page: 749
  year: 2006
  ident: BFng446_CR38
  publication-title: Bone
  doi: 10.1016/j.bone.2005.11.017
– volume: 371
  start-page: 1505
  year: 2008
  ident: BFng446_CR24
  publication-title: Lancet
  doi: 10.1016/S0140-6736(08)60599-1
– volume: 10
  start-page: 318
  year: 2009
  ident: BFng446_CR47
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2544
– ident: BFng446_CR48
– volume: 21
  start-page: 1738
  year: 2006
  ident: BFng446_CR1
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.060810
– volume: 24
  start-page: 37
  year: 2009
  ident: BFng446_CR62
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-008-9302-y
– volume: 39
  start-page: 906
  year: 2007
  ident: BFng446_CR60
  publication-title: Nat. Genet.
  doi: 10.1038/ng2088
– volume: 22
  start-page: 3307
  year: 2003
  ident: BFng446_CR26
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1206406
– volume: 7
  start-page: 403
  year: 1991
  ident: BFng446_CR51
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/BF00145007
– volume: 125
  start-page: 509
  year: 2006
  ident: BFng446_CR25
  publication-title: Cell
  doi: 10.1016/j.cell.2006.02.049
– volume: 11
  start-page: 530
  year: 1996
  ident: BFng446_CR53
  publication-title: J. Bone Miner. Res.
  doi: 10.1002/jbmr.5650110414
– volume: 11
  start-page: 926
  year: 1997
  ident: BFng446_CR35
  publication-title: Genes Dev.
  doi: 10.1101/gad.11.7.926
– volume: 96
  start-page: 8156
  year: 1999
  ident: BFng446_CR41
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.96.14.8156
– volume: 17
  start-page: R122
  year: 2008
  ident: BFng446_CR67
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddn288
– volume: 78
  start-page: 9
  year: 2006
  ident: BFng446_CR15
  publication-title: Calcif. Tissue Int.
  doi: 10.1007/s00223-005-0127-3
– volume: 104
  start-page: 1248
  year: 2007
  ident: BFng446_CR43
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0609149104
– volume: 386
  start-page: 532
  year: 2009
  ident: BFng446_CR33
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2009.06.071
– volume: 32
  start-page: 381
  year: 2008
  ident: BFng446_CR22
  publication-title: Genet. Epidemiol.
  doi: 10.1002/gepi.20303
– volume: 24
  start-page: 2543
  year: 2005
  ident: BFng446_CR46
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600729
– volume: S79
  start-page: 2290
  year: 2006
  ident: BFng446_CR59
  publication-title: Am. J. Hum. Genet.
– volume: 2
  start-page: e124
  year: 2005
  ident: BFng446_CR4
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.0020124
– volume: 9
  start-page: 135
  year: 2003
  ident: BFng446_CR5
  publication-title: Trends Mol. Med.
  doi: 10.1016/S1471-4914(03)00030-3
– volume: 117
  start-page: 2459
  year: 2007
  ident: BFng446_CR28
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI31960
– volume: 7
  start-page: 390
  year: 1997
  ident: BFng446_CR14
  publication-title: Osteoporos. Int.
  doi: 10.1007/BF01623782
– volume: 408
  start-page: 106
  year: 2000
  ident: BFng446_CR44
  publication-title: Nature
  doi: 10.1038/35040593
– volume: 12
  start-page: 527
  year: 2004
  ident: BFng446_CR52
  publication-title: Eur. J. Hum. Genet.
  doi: 10.1038/sj.ejhg.5201188
– volume: 145
  start-page: 255
  year: 2006
  ident: BFng446_CR9
  publication-title: Ann. Intern. Med.
  doi: 10.7326/0003-4819-145-4-200608150-00005
– volume: 40
  start-page: 489
  year: 2008
  ident: BFng446_CR19
  publication-title: Nat. Genet.
  doi: 10.1038/ng0508-489
– volume: 22
  start-page: 173
  year: 2007
  ident: BFng446_CR3
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/jbmr.060806
– volume: 110
  start-page: 281
  year: 1979
  ident: BFng446_CR55
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/oxfordjournals.aje.a112813
– volume: 38
  start-page: 904
  year: 2006
  ident: BFng446_CR57
  publication-title: Nat. Genet.
  doi: 10.1038/ng1847
– volume: 84
  start-page: 780
  year: 2009
  ident: BFng446_CR36
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2009.05.005
– volume: 7
  start-page: 188
  year: 2006
  ident: BFng446_CR32
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-7-188
– volume: 34
  start-page: 195
  year: 2004
  ident: BFng446_CR72
  publication-title: Bone
  doi: 10.1016/j.bone.2003.10.001
– ident: BFng446_CR66
– volume: 33
  start-page: 301
  year: 2008
  ident: BFng446_CR69
  publication-title: Physiol. Genomics
  doi: 10.1152/physiolgenomics.00028.2008
– volume: 81
  start-page: 559
  year: 2007
  ident: BFng446_CR70
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/519795
– volume: 299
  start-page: 574
  year: 2003
  ident: BFng446_CR37
  publication-title: Science
  doi: 10.1126/science.1075994
– volume: 292
  start-page: 2105
  year: 2004
  ident: BFng446_CR6
  publication-title: J. Am. Med. Assoc.
  doi: 10.1001/jama.292.17.2105
– volume: 30
  start-page: 97
  year: 2002
  ident: BFng446_CR63
  publication-title: Nat. Genet.
  doi: 10.1038/ng786
– volume: 40
  start-page: 609
  year: 2008
  ident: BFng446_CR18
  publication-title: Nat. Genet.
  doi: 10.1038/ng.122
– volume: 165
  start-page: 1328
  year: 2007
  ident: BFng446_CR56
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/aje/kwm021
– volume: 299
  start-page: 1277
  year: 2008
  ident: BFng446_CR10
  publication-title: J. Am. Med. Assoc.
  doi: 10.1001/jama.299.11.1277
– volume: 3
  start-page: e90
  year: 2006
  ident: BFng446_CR8
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.0030090
– volume: 20
  start-page: 1858
  year: 2005
  ident: BFng446_CR42
  publication-title: J. Bone Miner. Res.
  doi: 10.1359/JBMR.050611
– volume: 449
  start-page: 851
  year: 2007
  ident: BFng446_CR23
  publication-title: Nature
  doi: 10.1038/nature06258
– volume: 9
  start-page: 356
  year: 2008
  ident: BFng446_CR11
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2344
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Snippet Fernando Rivadeneira and colleagues report findings from a large-scale meta-analysis of genome-wide association studies for bone mineral density. The loci...
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed...
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SubjectTerms Agriculture
Animal Genetics and Genomics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Bone Density - genetics
Bone mineral density
Bones
Cancer Research
Clinical medicine
Complications and side effects
Density
Femur - physiology
Fractures
Fractures, Bone - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Gene Function
Genes
Genetic aspects
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genome-Wide Association Study
Genotype
Human Genetics
Humans
Lumbar Vertebrae - physiology
Medical research
Meta-analysis
Osteoporosis
Physiological aspects
Polymorphism, Single Nucleotide
Quality control
Quantitative Trait Loci
Risk Factors
Single nucleotide polymorphisms
Spine
White People - genetics
Title Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
URI https://link.springer.com/article/10.1038/ng.446
https://www.ncbi.nlm.nih.gov/pubmed/19801982
https://www.proquest.com/docview/222635162
https://www.proquest.com/docview/21218912
https://www.proquest.com/docview/733946107
https://pubmed.ncbi.nlm.nih.gov/PMC2783489
Volume 41
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