Role of Rab27 in synaptic transmission at the squid giant synapse

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 41; pp. 16003 - 16008
• Main Authors: Yu, Eunah, Kanno, Eiko, Choi, Soonwook, Sugimori, Mutsuyuki, Moreira, Jorge E, Llinás, Rodolfo R, Fukuda, Mitsunori
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 14.10.2008; National Acad Sciences
• Subjects: Action Potentials; Animals; Antibodies; Antibodies - pharmacology; Biological Sciences; Biological Transport; Calcium; Calcium - metabolism; Cell membranes; Complementary DNA; Decapodiformes; Dyes; Electrical Synapses - physiology; Electrophysiology; Eukaryotes; Exocytosis; Fluorescence; Marine; Membranes; Microscopy; Molecular Sequence Data; PC12 cells; Proteins; rab GTP-Binding Proteins - analysis; rab GTP-Binding Proteins - immunology; rab GTP-Binding Proteins - physiology; Squid; Synapses; Synaptic Vesicles - chemistry; Synaptic Vesicles - metabolism; Synaptosomes

Small GTPase Rab is a member of a large family of Ras-related proteins, highly conserved in eukaryotic cells, and thought to regulate specific type(s) and/or specific step(s) in intracellular membrane trafficking. Given our interest in synaptic transmission, we addressed the possibility that Rab27 (...