Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese

• Published in: BMC medical genetics Vol. 19; no. 1; p. 96
• Main Authors: Sakiyama, Masayuki, Matsuo, Hirotaka, Nakaoka, Hirofumi, Kawamura, Yusuke, Kawaguchi, Makoto, Higashino, Toshihide, Nakayama, Akiyoshi, Akashi, Airi, Ueyama, Jun, Kondo, Takaaki, Wakai, Kenji, Sakurai, Yutaka, Yamamoto, Ken, Ooyama, Hiroshi, Shinomiya, Nariyoshi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.06.2018; BioMed Central; BMC
• Subjects: Arthritis; Breast cancer; Breast carcinoma; Breast carcinoma amplified sequence 3 (BCAS3); Collaboration; Complications and side effects; Deoxyribonucleic acid; DNA; Estrogen receptors; Gene deletion; Gene expression; Genes; Genome-wide association studies; Genomes; Genotypes; Genotyping; Gout; Hyperuricemia; KCNQ1 protein; Linkage disequilibrium; Metabolism; Population studies; Potassium channels (voltage-gated); Potassium voltage-gated Channel subfamily Q member 1 (KCNQ1); Primers; Regulatory factor X3 (RFX3); Replication; Rheumatism; Risk factors; Single nucleotide polymorphisms (SNP); Urate; Uric acid; Japan; China; United States > US; Regulatory factor X3 (RFX3); Potassium voltage-gated Channel subfamily Q member 1 (KCNQ1); Single nucleotide polymorphisms (SNP); Uric acid; Breast carcinoma amplified sequence 3 (BCAS3); Urate

Gout is a common disease resulting from hyperuricemia which causes acute arthritis. A recent genome-wide association study (GWAS) of gout identified three new loci for gout in Han Chinese: regulatory factor X3 (RFX3), potassium voltage-gated channel subfamily Q member 1 (KCNQ1), and breast carcinoma...