Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk

• Published in: Cardiovascular research Vol. 119; no. 7; pp. 1524 - 1536
• Main Authors: Forteza, Maria J, Berg, Martin, Edsfeldt, Andreas, Sun, Jangming, Baumgartner, Roland, Kareinen, Ilona, Casagrande, Felipe Beccaria, Hedin, Ulf, Zhang, Song, Vuckovic, Ivan, Dzeja, Petras P, Polyzos, Konstantinos A, Gisterå, Anton, Trauelsen, Mette, Schwartz, Thue W, Dib, Lea, Herrmann, Joerg, Monaco, Claudia, Matic, Ljubica, Gonçalves, Isabel, Ketelhuth, Daniel F J
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 04.07.2023
• Subjects: Animals; atherosclerosis; Atherosclerosis - genetics; Cardiac and Cardiovascular Systems; Cardiovascular Diseases; Clinical Medicine; CVD; Heart Disease Risk Factors; Humans; immunometabolism; inflammation; Inflammation - genetics; Kardiologi; Klinisk medicin; Medical and Health Sciences; Medicin och hälsovetenskap; Mice; Mice, Knockout, ApoE; Original; PDK; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Risk Factors; atherosclerosis; CVD; inflammation; immunometabolism; PDK

Abstract Aims Recent studies have revealed a close connection between cellular metabolism and the chronic inflammatory process of atherosclerosis. While the link between systemic metabolism and atherosclerosis is well established, the implications of altered metabolism in the artery wall are less un...