Serum Myostatin and IGF-1 as Gender-Specific Biomarkers of Frailty and Low Muscle Mass in Community-Dwelling Older Adults

• Published in: The Journal of nutrition, health & aging Vol. 23; no. 10; pp. 979 - 986
• Main Authors: Chew, Justin, Tay, L., Lim, J.P., Leung, B.P., Yeo, A., Yew, S., Ding, Y.Y., Lim, W.S.
• Format: Journal Article
• Language: English
• Published: Paris Elsevier Masson SAS 01.12.2019; Springer Paris; Springer Nature B.V; Elsevier
• Subjects: Aged; Aging; Biomarkers; Biomarkers - blood; blood sampling; blood serum; body mass index; cognition; comorbidity; Cross-Sectional Studies; dual-energy X-ray absorptiometry; elderly; Female; Frailty; Frailty - blood; Frailty - diagnosis; Gender; gender differences; Gender Identity; Geriatrics/Gerontology; Humans; IGF-1; Independent Living; inflammation; insulin-like growth factor I; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factors; interleukin-6; lean body mass; leukocyte count; Longitudinal Studies; Male; Medicine; Medicine & Public Health; men; Musculoskeletal system; myostatin; Myostatin - blood; Neurosciences; Nutrition; nutritional status; Older people; physical activity; prediction; Primary Care Medicine; Prospective Studies; Quality of Life Research; regression analysis; Sarcopenia; Sarcopenia - blood; Sarcopenia - diagnosis; Singapore; skeletal muscle; women; Singapore; Sarcopenia; frailty; IGF-1; myostatin

(i) To investigate serum myostatin (absolute and normalized for total body lean mass (TBLM)) and IGF-1 as biomarkers of frailty and low relative appendicular skeletal muscle mass (RASM) in older adults, and; (ii)to examine gender differences in the association of serum myostatin and IGF-1 levels wit...