Mechanisms underlying the promotion of functional recovery by deferoxamine after spinal cord injury in rats

• Published in: Neural regeneration research Vol. 12; no. 6; pp. 959 - 968
• Main Authors: Hao, Jian, Li, Bo, Duan, Hui-quan, Zhao, Chen-xi, Zhang, Yan, Sun, Chao, Pan, Bin, Liu, Chang, Kong, Xiao-hong, Yao, Xue, Feng, Shi-qing
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.06.2017; Medknow Publications & Media Pvt. Ltd; Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin, China; Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China%School of Medicine, Nankai University, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Apoptosis; Care and treatment; caspase-3; Complications and side effects; Deferoxamine; Diagnosis; Dosage and administration; Free radicals; Health aspects; Laboratory animals; nerve regeneration; spinal cord injury; deferoxamine; tumor necrosis factor-α; interleukin-1β; apoptosis; iron; anti-inflammatory; glial scar; proinflammatory; rats; motor function; lipid peroxidation; neural regeneration; Proteins; Rodents; Spinal cord injuries; Tumor necrosis factor-TNF; 功能恢复; 大鼠; 机制; 白细胞介素-1β; 肿瘤坏死因子-α; 脊髓损伤; 铁离子浓度; New York; United States > US; China; spinal cord injury; proinflammatory; lipid peroxidation; interleukin-1β; apoptosis; deferoxamine; neural regeneration; glial scar; tumor necrosis factor-α; anti-inflammatory; iron; nerve regeneration; motor function; rats; apoptosis; interleukin-1β

Deferoxamine, a clinically safe drug used for treating iron overload, also repairs spinal cord injury although the mechanism for this action remains unknown. Here, we determined whether deferoxamine was therapeutic in a rat model of spinal cord injury and explored potential mechanisms for this effec...