Widespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome

• Published in: PLoS biology Vol. 2; no. 12; p. e391
• Main Authors: Athanasiadis, Alekos, Rich, Alexander, Maas, Stefan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2004; Public Library of Science (PLoS)
• Subjects: 5' Untranslated Regions; Adenosine - chemistry; Adenosine Deaminase - metabolism; Alternative Splicing; Alu Elements; Animals; Base Pair Mismatch; Bioinformatics/Computational Biology; Brain - metabolism; Caenorhabditis elegans; Cell Biology; Computational Biology; Conserved Sequence; Databases, Genetic; DNA, Complementary - metabolism; Exons; Expressed Sequence Tags; Genetics; Genetics/Genomics/Gene Therapy; Genome; Genome, Human; Homo (Human); Humans; Inosine - chemistry; Introns; Kinases; Models, Genetic; Models, Statistical; Molecular Biology/Structural Biology; Molecular Sequence Data; Proteins; Proteome; Receptors, G-Protein-Coupled - metabolism; Ribonucleic acid; RNA; RNA - metabolism; RNA Editing; RNA Processing, Post-Transcriptional; RNA, Messenger - metabolism; Software; Brain; Alternative Splicing; RNA; Exons; RNA Editing; Humans; Databases, Genetic; Molecular Sequence Data; Base Pair Mismatch; Conserved Sequence; Adenosine Deaminase; Expressed Sequence Tags; Adenosine; RNA Processing, Post-Transcriptional; Introns; Computational Biology; Receptors, G-Protein-Coupled; Proteome; Models, Statistical; Caenorhabditis elegans; Animals; 5' Untranslated Regions; Inosine; Models, Genetic; Software; Genome; Genome, Human; Alu Elements; RNA, Messenger; DNA, Complementary

RNA editing by adenosine deamination generates RNA and protein diversity through the posttranscriptional modification of single nucleotides in RNA sequences. Few mammalian A-to-I edited genes have been identified despite evidence that many more should exist. Here we identify intramolecular pairs of...