Resting-State Functional and Structural Connectivity Within an Insula–Amygdala Route Specifically Index State and Trait Anxiety

• Published in: Biological psychiatry (1969) Vol. 73; no. 1; pp. 85 - 92
• Main Authors: Baur, Volker, Hänggi, Jürgen, Langer, Nicolas, Jäncke, Lutz
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2013; Elsevier
• Subjects: Adult; Amygdala; Amygdala - pathology; Amygdala - physiopathology; Anxiety - pathology; Anxiety - physiopathology; Biological and medical sciences; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Diffusion Tensor Imaging - methods; Diffusion Tensor Imaging - psychology; Functional Neuroimaging - methods; Functional Neuroimaging - psychology; Humans; insula; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - psychology; Medical sciences; Neural Pathways - physiology; Neural Pathways - physiopathology; Personality Inventory - statistics & numerical data; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; resting-state functional connectivity; state anxiety; structural connectivity; trait anxiety; state anxiety; resting-state functional connectivity; structural connectivity; Amygdala; insula; trait anxiety; Affect affectivity; Central nervous system; Basal ganglion; Personality; Encephalon; Rest; Anxiety; Insular cortex; Amygdaloid nucleus

Background Conjoint activity of the insula and amygdala has frequently been reported during emotional stimulation in general and in anxiety-related contexts in particular. However, direct connectivity between the insula and amygdala in this framework has received little attention so far. Studying wh...