E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 41; pp. 17493 - 17498
• Main Authors: Li, Da-Qiang, Ohshiro, Kazufumi, Reddy, Sirigiri Divijendra Natha, Pakala, Suresh B, Lee, Mong-Hong, Zhang, Yanping, Rayala, Suresh K, Kumar, Rakesh
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 13.10.2009; National Acad Sciences
• Subjects: Animals; Antibodies; Biological Sciences; Cancer; Cell Line; Cell lines; Chromatin; Deoxyribonucleic acid; DNA; DNA Damage; DNA Repair; Enzyme Stability; Fibroblasts - cytology; Fibroblasts - physiology; Gene expression regulation; Histone Deacetylases - chemistry; Histone Deacetylases - metabolism; Histone Deacetylases - radiation effects; histones; Humans; Ionizing radiation; Mice; mutants; Mutation; neoplasms; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; nucleosomes; photomorphogenesis; Physiological regulation; Plasmids; Proteases; Proteins; proteolysis; Radiation; Radiation, Ionizing; Regulator genes; Repressor Proteins - chemistry; Repressor Proteins - metabolism; Repressor Proteins - radiation effects; Trans-Activators; Transcription Factors - deficiency; Transcription Factors - genetics; Transcription Factors - metabolism; Ubiquitin - metabolism; ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; ubiquitination; Ubiquitins

Metastasis-associated protein 1 (MTA1), a component of the nucleosome remodeling and histone deacetylation (NuRD) complex, is widely upregulated in human cancers. However, the mechanism for regulating its protein stability remains unknown. Here we report that MTA1 is an ubiquitinated protein and tar...