Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 36; pp. 14501 - 14506
• Main Authors: Hikida, Takatoshi, Jaaro-Peled, Hanna, Seshadri, Saurav, Oishi, Kenichi, Hookway, Caroline, Kong, Stephanie, Wu, Di, Xue, Rong, Andradé, Manuella, Tankou, Stephanie, Mori, Susumu, Gallagher, Michela, Ishizuka, Koko, Pletnikov, Mikhail, Kida, Satoshi, Sawa, Akira
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 04.09.2007; National Acad Sciences
• Series: From the Cover
• Subjects: Animals; Behavior modeling; Behavior, Animal; Biological Sciences; Biomarkers; Disease models; Disease Models, Animal; Genes, Dominant - genetics; Genetics; Genotype & phenotype; Hippocampus; Human genetics; Humans; Lateral ventricles; Medical genetics; Mental illness; Mice; Mice, Transgenic; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurons; Phenotype; Rodents; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - genetics; Schizophrenia - physiopathology; Transgenic animals

Here, we report generation and characterization of Disrupted-In-Schizophrenia-1 (DISC1) genetically engineered mice as a potential model for major mental illnesses, such as schizophrenia. DISC1 is a promising genetic risk factor for major mental illnesses. In this transgenic model, a dominant-negati...