A novel high-throughput neutralization assay for supporting clinical evaluations of human cytomegalovirus vaccines - Tang, Aimin; Li, Fengsheng; Freed, Daniel C.; Finnefrock, Adam C.; Casimiro, Danilo R.; Wang, Dai; Fu, Tong-Ming (Vaccine, 2011)
Keywords: Adolescent; Adult; Allergy and Immunology; Animals; antigens; antiviral properties; Applied microbiology; Automation; Biological and medical sciences; blood serum; Clinical trials; congenital abnormalities; Cytomegalovirus; Cytomegalovirus Vaccines - immunology; cytopathogenicity; Female; females; fetus; Fetuses; Fundamental and applied biological sciences. Psychology; HCMV vaccines; High-Throughput Screening Assays - methods; Human betaherpesvirus 5; Human cytomegalovirus; human diseases; Human herpesvirus 5; Humans; immunity; Infections; Macaca mulatta; Microbiology; Miscellaneous; Neutralization; neutralization tests; Neutralization Tests - methods; Neutralizing antibodies; Pregnancy; Proteins; serological surveys; Studies; vaccination; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Viral infections; Viral neutralization; Virology; women; Young Adult; HCMV; NT50; Neutralizing antibodies; Viral neutralization; CPE; IRD; IE; HCMV vaccines; IMS; GMT; Human cytomegalovirus; cytopathic effect; immunostaining; near-infrared dye; human cytomegalovirus; geometric mean titers; immediate early; serum dilution titers to neutralize 50% input virions; Virus; Herpesviridae; Vaccine; Betaherpesvirinae; Neutralizing antibody; Neutralization