DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 49; pp. 19351 - 19356
• Main Authors: Sinclair, Kevin D, Allegrucci, Cinzia, Singh, Ravinder, Gardner, David S, Sebastian, Sonia, Bispham, Jayson, Thurston, Alexandra, Huntley, John F, Rees, William D, Maloney, Christopher A, Lea, Richard G, Craigon, Jim, McEvoy, Tom G, Young, Lorraine E
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 04.12.2007; National Acad Sciences
• Subjects: Amino acids; Animals; Animals, Newborn - immunology; Animals, Newborn - metabolism; Biological Sciences; Blood plasma; Blood Pressure; Body Composition - drug effects; Deoxyribonucleic acid; Diet; DNA; DNA methylation; DNA Methylation - drug effects; Embryo, Mammalian - metabolism; Embryos; Epigenesis, Genetic - drug effects; epigenetics; ewes; Female; Fertilization; Folic Acid - administration & dosage; Genetic loci; Genomics; Genotype & phenotype; Glucose - metabolism; Granulosa cells; Heart Rate - drug effects; immune response; Immunity; Insulin; Insulin Resistance; Male animals; maternal nutrition; methionine; Methionine - administration & dosage; Methylation; nutritional status; oocytes; periconceptional diet; Pregnancy; Pregnancy - drug effects; Pregnancy - genetics; Pregnancy - metabolism; Pregnancy Outcome; progeny; Sheep; Sheep - embryology; Sheep - metabolism; Vitamin B; Vitamin B 12 - administration & dosage; Vitamin B Complex - administration & dosage; vitamin B12

A complex combination of adult health-related disorders can originate from developmental events that occur in utero. The periconceptional period may also be programmable. We report on the effects of restricting the supply of specific B vitamins (i.e., B₁₂ and folate) and methionine, within normal ph...