Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125, STF2.HA1 SI)

• Published in: Vaccine Vol. 29; no. 31; pp. 4897 - 4902
• Main Authors: Taylor, David N., Treanor, John J., Strout, Cynthia, Johnson, Casey, Fitzgerald, Theresa, Kavita, Uma, Ozer, Karen, Tussey, Lynda, Shaw, Alan
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 12.07.2011; Elsevier; Elsevier Limited
• Subjects: Adjuvants, Immunologic - administration & dosage; Aged; Aged, 80 and over; agonists; Allergy and Immunology; Antibodies, Viral - blood; Applied microbiology; Biological and medical sciences; blood serum; C-reactive protein; Cell culture; Cytokines; Elderly; Escherichia coli; Escherichia coli - genetics; Female; Flagellin; Flagellin - administration & dosage; Flagellin - genetics; Frailty; Fundamental and applied biological sciences. Psychology; Hemagglutination Inhibition Tests; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - immunology; hemagglutinins; Humans; Immune response; Influenza; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - immunology; Influenza Vaccines - administration & dosage; Influenza Vaccines - adverse effects; Influenza Vaccines - immunology; Influenza virus; Ligands; Male; Microbiology; Older people; Orthomyxoviridae; Pain; Proteins; Recombinant; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - immunology; seroconversion; Toll-like receptor 5; Toll-Like Receptor 5 - agonists; vaccination; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - adverse effects; Vaccines, Synthetic - immunology; viruses; Young adults; United States > US; Toll-like receptor 5; Flagellin; Vaccine; Elderly; Influenza; Recombinant; Human; Toll like receptor 5; Immune response; Hemagglutinin; Infection; Viral disease; Influenza A

Influenza vaccines perform poorly in the elderly with reduced serological response and vaccine efficacy. We evaluated a novel influenza vaccine consisting of the globular head of the HA1 domain of the A/Solomon Islands/3/2006 (H1N1) influenza virus (VAX125) genetically fused to the TLR5 ligand, flag...