Transition state theory for enzyme kinetics

• Published in: Archives of biochemistry and biophysics Vol. 582; pp. 10 - 17
• Main Author: Truhlar, Donald G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2015
• Subjects: Enzyme Activation; Enzyme kinetics; enzymes; Enzymes - metabolism; Free energy; Gibbs free energy; Kinetics; Models, Biological; Quantum effects; Quantum Theory; Thermodynamics; Transition state theory; Tunneling; Tunneling; Transition state theory; Quantum effects; Enzyme kinetics; Free energy

[Display omitted] •I discuss the foundations of transition state theory.•The use of free energy surfaces is explained.•I emphasize ensemble-averaged variational transition state theory for enzyme kinetics.•Quantum effects – tunneling and zero point energy – have important effects on rates. This arti...