A Tissue-Engineered Muscle Repair Construct for Functional Restoration of an Irrecoverable Muscle Injury in a Murine Model

• Published in: Tissue engineering. Part A Vol. 17; no. 17-18; pp. 2291 - 2303
• Main Authors: Machingal, Masood A., Corona, Benjamin T., Walters, Thomas J., Kesireddy, Venu, Koval, Christine N., Dannahower, Ashley, Zhao, Weixin, Yoo, James J., Christ, George J.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.09.2011
• Subjects: Animals; Care and treatment; Cells, Cultured; Cellular biology; Diagnosis; Female; Immunochemistry; Injuries; Male; Mice; Mice, Nude; Microscopy, Electron, Scanning; Muscle, Skeletal - cytology; Muscle, Skeletal - injuries; Muscle, Skeletal - metabolism; Muscle, Skeletal - ultrastructure; Muscular system; Original; Original Articles; Rats; Rodents; Stem Cells - cytology; Stem Cells - metabolism; Stem Cells - ultrastructure; Tissue engineering; Tissue Engineering - methods; Tissue Scaffolds - chemistry; Wounds and injuries; United States

There are no effective clinical treatments for volumetric muscle loss (VML) resulting from traumatic injury, tumor excision, or other degenerative diseases of skeletal muscle. The goal of this study was to develop and characterize a more clinically relevant tissue-engineered muscle repair (TE-MR) co...