How the brain can rewire itself after an injury： the lesson from hemispherectomy

Does a post-lesional rewiring exist in the central nervous system （CNS）？ Whereas neuroimaging and neuromodulation techniques illustrate the extensive cortical reshaping after a brain injury, the remodeling of ascending and descending neuronal pathway is more difficult to be investigated. Here, we di...

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Bibliographic Details
Published inNeural regeneration research Vol. 12; no. 9; pp. 1426 - 1427
Main Authors Sebastianelli, Luca, Saltuari, Leopold, Nardone, Raffaele
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.09.2017
Medknow Publications & Media Pvt. Ltd
Department of Neurology, Hochzirl Hospital, Zirl, Austria%Department of Neurology, Franz Tappeiner Hospital, Meran, Italy
Department of Neurorehabilitation, Hospital of Sterzing, Sterzing, Italy%Department of Neurorehabilitation, Hospital of Sterzing, Sterzing, Italy
Department of Neurology, Christian Doppler Klinik, Paracellsus Medical University, Salzburg, Austria
Research Unit for Neurorehabilitation of South Tyrol, Bozen, Italy
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Animals
Brain injuries
Brain research
Care and treatment
Convulsions & seizures
Epilepsy
Hemispherectomy
Human subjects
Injuries
Nerve regeneration
Neuroplasticity
Patient outcomes
Pediatrics
Physiological aspects
Transcranial magnetic stimulation
中枢神经系统
切除术
动物模型
半球
受伤
大脑
神经通路
调节技术
Online AccessGet full text
ISSN1673-5374
1876-7958
DOI10.4103/1673-5374.215247

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Summary:Does a post-lesional rewiring exist in the central nervous system （CNS）？ Whereas neuroimaging and neuromodulation techniques illustrate the extensive cortical reshaping after a brain injury, the remodeling of ascending and descending neuronal pathway is more difficult to be investigated. Here, we discuss how the studies dealing with hemispherectomy （HS） can provide interesting information about the functional and anatomical reorganization which take place after an extensive unilateral lesion. Indeed, studies in humans and animal models of HS clearly illustrate that the brain is capable of a widespread rewiring between the contralesional cortices and the subcortical structures as well as the medullary segments linked to the affected side of the body.
Bibliography:Does a post-lesional rewiring exist in the central nervous system （CNS）？ Whereas neuroimaging and neuromodulation techniques illustrate the extensive cortical reshaping after a brain injury, the remodeling of ascending and descending neuronal pathway is more difficult to be investigated. Here, we discuss how the studies dealing with hemispherectomy （HS） can provide interesting information about the functional and anatomical reorganization which take place after an extensive unilateral lesion. Indeed, studies in humans and animal models of HS clearly illustrate that the brain is capable of a widespread rewiring between the contralesional cortices and the subcortical structures as well as the medullary segments linked to the affected side of the body.
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ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.215247