Chronic variable stress alters hypothalamic-pituitary-adrenal axis function in the female mouse

• Published in: Physiology & behavior Vol. 209; p. 112613
• Main Authors: Borrow, Amanda P., Heck, Ashley L., Miller, Alex M., Sheng, Julietta A., Stover, Sally A., Daniels, Renata M., Bales, Natalie J., Fleury, Theodore K., Handa, Robert J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2019
• Subjects: anxiety; arginine vasopressin; behavior change; Chronic variable stress; Corticosterone; Corticotropin releasing hormone (CRH); corticotropin-releasing hormone; Female; females; gene expression; hypertrophy; messenger RNA; mice; Oxytocin; patients; risk; secretion; tail suspension test; Vasopressin (AVP); Female; Corticotropin releasing hormone (CRH); Oxytocin; Vasopressin (AVP); Corticosterone; Chronic variable stress

Chronic stress is often associated with a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, which can greatly increase risk for a number of stress-related diseases, including neuropsychiatric disorders. Despite a striking sex-bias in the prevalence of many of these disorders, few precl...