Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila

• Published in: The EMBO journal Vol. 42; no. 8; pp. e110454 - n/a
• Main Authors: Ikegawa, Yuko, Combet, Christophe, Groussin, Mathieu, Navratil, Vincent, Safar‐Remali, Sabrina, Shiota, Takuya, Aouacheria, Abdel, Yoo, Sa Kan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.04.2023; Springer Nature B.V; EMBO Press; John Wiley and Sons Inc
• Subjects: Animals; Apoptosis; Apoptosis - physiology; Autophagy; BH3‐only protein; Caspase; Cell death; Drosophila; Drosophila - genetics; Drosophila Proteins - metabolism; EMBO07; Feedback; Feedback loops; Fruit flies; Gene duplication; Homology; Insects; Life Sciences; Phylogeny; Positive feedback; Proteins; Proto-Oncogene Proteins c-bcl-2 - metabolism; Sensors; BH3‐only protein; apoptosis; cell death; caspase; BH3-only protein; Drosophila; apoptosis BH3-only protein caspase cell death Drosophila Subject Categories Autophagy & Cell Death; Drosophila Subject Categories Autophagy & Cell Death

Cells need to sense stresses to initiate the execution of the dormant cell death program. Since the discovery of the first BH3‐only protein Bad, BH3‐only proteins have been recognized as indispensable stress sensors that induce apoptosis. BH3‐only proteins have so far not been identified in Drosophi...