Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 51; pp. 21695 - 21700
• Main Authors: Löhr, Ulrike, Chung, Ho-Ryun, Beller, Mathias, Jäckle, Herbert
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.12.2009; National Acad Sciences
• Subjects: Animals; Binding sites; Biological Sciences; Boundaries; Capicua repressor; Cells; Drosophila; Drosophila - embryology; Drosophila - genetics; Drosophila melanogaster; Drosophila Proteins - physiology; Embryos; Enhancers; Gene Duplication; Gene expression; gene expression regulation; Gene Expression Regulation - physiology; Genes; Graphics; Head; HMGB Proteins - physiology; Homeodomain Proteins - physiology; insect development; Insects; Kinases; Messenger RNA; protein kinases; protein phosphorylation; Protein-tyrosine kinase receptors; receptor tyrosine kinase; Repression; Repressor Proteins - physiology; Repressors; Stripes; Thorax; Torso; Trans-Activators - physiology; Transcription activation; transcription factors

Bicoid (Bcd) is the anterior determinant in DROSOPHILA: Accordingly, loss of Bcd causes loss of head and thorax and their replacement with posterior structures. bcd mRNA is maternally deposited at the anterior pole and Bcd forms an anterior-to-posterior (AP) concentration gradient. The expression of...