Mitochondrial glutathione: Features, regulation and role in disease

• Published in: Biochimica et biophysica acta Vol. 1830; no. 5; pp. 3317 - 3328
• Main Authors: Marí, Montserrat, Morales, Albert, Colell, Anna, García-Ruiz, Carmen, Kaplowitz, Neil, Fernández-Checa, José C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2013
• Subjects: amyloid; Animals; antioxidants; Antioxidants - metabolism; Biological Transport; cell death; Cholesterol; Cytosol - metabolism; death; disease resistance; diseases; enzymes; glutathione; Glutathione - metabolism; GSH; Humans; hypoxia; mammals; mitochondria; Mitochondria - metabolism; Mitochondrion; Neurodegeneration; oxidants; oxidative stress; Oxidative Stress - physiology; oxygen consumption; pathogenesis; reactive oxygen species; regulations; Steatohepatitis; toxicity; tumor necrosis factors; Mitochondrion; Neurodegeneration; GSH; Steatohepatitis; Cholesterol

Mitochondria are the powerhouse of mammalian cells and the main source of reactive oxygen species (ROS) associated with oxygen consumption. In addition, they also play a strategic role in controlling the fate of cells through regulation of death pathways. Mitochondrial ROS production fulfills a sign...